β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

AmpC β-lactamases are clinically important cephalosporinases encoded on the
chromosomes of many of the Enterobacteriaceae and a few other organisms, where they …

Extended-spectrum β-lactamases (ESBLs) are a group of plasmid-mediated, diverse,
complex and rapidly evolving enzymes that are posing a major therapeutic challenge today …

Extended-spectrum β-lactamases (ESBLs) are a rapidly evolving group of β-lactamases
which share the ability to hydrolyze third-generation cephalosporins and aztreonam yet are …

Therapeutic options for infections caused by gram-negative organisms expressing plasmid-
mediated AmpC β-lactamases are limited because these organisms are usually resistant to …

Extended spectrum β-lactamase (ESBL)-producing organisms pose unique challenges to
clinical microbiologists, clinicians, infection control professionals and antibacterial-discovery …

Gram-negative bacilli with acquired metallo-β-lactamase (MBL) production have been
increasingly reported in some countries, necessitating their detection. The aim of this study …

Abstract β-lactams have a long history in the treatment of infectious diseases, though their
use has been and continues to be confounded by the development of resistance in target …

Seventeen multiple-antibiotic-resistant nonpathogenic Escherichia coli strains of human,
animal, and food origins showed a wide variety of antibiotic resistance genes, many of them …

We sequenced the genomes of 10 Salmonella enterica serovar Infantis isolates containing
bla CTX-M-65 obtained from chicken, cattle, and human sources collected between 2012 …