Takotsubo syndrome (TTS) is identified as an acute severe ventricular systolic dysfunction,
which is usually characterized by reversible and transient akinesia of walls of the ventricle in …

Brugada syndrome (BrS) is a rare hereditary arrhythmia disorder, with a distinctive ECG
pattern, correlated with an increased risk of ventricular arrhythmias and sudden cardiac …

Summary Background Brugada syndrome (BrS) is a cardiac channelopathy that can result in
sudden cardiac death (SCD). SCN5A is the most frequent gene linked to BrS, but the …

Aims Human-induced pluripotent stem cell-cardiomyocytes (hiPSC-CMs) are widely used to
study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium …

Cardiovascular disease (CVD) remains the leading cause of death worldwide. Natural
compounds extracted from medicinal plants characterized by diverse biological activities …

Brugada syndrome (BrS) is an inherited and rare cardiac arrhythmogenic disease
associated with an increased risk of ventricular fibrillation and sudden cardiac death …

Arrhythmias in Brugada syndrome patients originate in the right ventricular outflow tract
(RVOT). Over the past few decades, the characterization of the unique anatomy and …

Nav1. 5 is the predominant cardiac sodium channel subtype, encoded by the SCN5A gene,
which is involved in the initiation and conduction of action potentials throughout the heart …

Aims: Some gene variants in the sodium channels, as well as calcium channels, have been
associated with Brugada syndrome (BrS). However, the investigation of the human cellular …

Brugada syndrome (BrS) is an inherited cardiac channelopathy first diagnosed in 1992 but
still considered a challenging disease in terms of diagnosis, arrhythmia risk prediction …