The strategies to cure cancer patients by eradicating cancer stem-like cells
Y Mai, J Su, C Yang, C Xia, L Fu - Molecular Cancer, 2023 - Springer
Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …
Differentiation of the tumor microenvironment: are CAFs the Organizer?
M Kochetkova, MS Samuel - Trends in cell biology, 2022 - cell.com
Cancers contain a suite of genetically stable cells within an extracellular matrix, collectively
termed the tumor microenvironment (TME). The TME strongly influences disease outcome …
termed the tumor microenvironment (TME). The TME strongly influences disease outcome …
[HTML][HTML] Understanding the impact of feedback regulations on blood cell production and leukemia dynamics using model analysis and simulation of clinically relevant …
Acute myeloid leukemia (AML) is a paradigmatic example of a stem cell-driven cancer. AML
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …
A longitudinal single-cell atlas of treatment response in pediatric AML
Pediatric acute myeloid leukemia (pAML) is characterized by heterogeneous cellular
composition, driver alterations and prognosis. Characterization of this heterogeneity and …
composition, driver alterations and prognosis. Characterization of this heterogeneity and …
Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia
C Larrue, S Mouche, S Lin, F Simonetta… - Leukemia, 2023 - nature.com
Mitochondrial metabolism recently emerged as a critical dependency in acute myeloid
leukemia (AML). The shape of mitochondria is tightly regulated by dynamin GTPase …
leukemia (AML). The shape of mitochondria is tightly regulated by dynamin GTPase …
Whole-genome screens reveal regulators of differentiation state and context-dependent migration in human neutrophils
NM Belliveau, MJ Footer, E Akdoǧan… - Nature …, 2023 - nature.com
Neutrophils are the most abundant leukocyte in humans and provide a critical early line of
defense as part of our innate immune system. We perform a comprehensive, genome-wide …
defense as part of our innate immune system. We perform a comprehensive, genome-wide …
Nanozymes: a new approach for leukemia therapy
W Wang, J An, R Zhao, X Geng, W Jiang… - Journal of Materials …, 2024 - pubs.rsc.org
Leukemia is a type of clonal disorders of hematopoietic stem and progenitor cells
characterized by bone marrow failure, differentiation arrest, and lineage skewing. Despite …
characterized by bone marrow failure, differentiation arrest, and lineage skewing. Despite …
Differential regulation of H3K9/H3K14 acetylation by small molecules drives neuron-fate-induction of glioma cell
X Liu, C Guo, T Leng, Z Fan, J Mai, J Chen, J Xu… - Cell Death & …, 2023 - nature.com
Differentiation therapy using small molecules is a promising strategy for improving the
prognosis of glioblastoma (GBM). Histone acetylation plays an important role in cell fate …
prognosis of glioblastoma (GBM). Histone acetylation plays an important role in cell fate …
Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells
C Wang, R Nistala, M Cao, Y Pan, M Behrens, D Doll… - Cell reports, 2023 - cell.com
Leukemic-stem-cell-specific targeting may improve the survival of patients with acute
myeloid leukemia (AML) by avoiding the ablative effects of standard regimens on normal …
myeloid leukemia (AML) by avoiding the ablative effects of standard regimens on normal …
[HTML][HTML] SUMOylation inhibitor TAK-981 (subasumstat) synergizes with 5-azacytidine in preclinical models of acute myeloid leukemia
L Gabellier, M De Toledo, M Chakraborty, D Akl… - …, 2024 - ncbi.nlm.nih.gov
Acute myeloid leukemias (AML) are severe hematomalignancies with dismal prognosis. The
post-translational modification SUMOylation plays key roles in leukemogenesis and AML …
post-translational modification SUMOylation plays key roles in leukemogenesis and AML …