Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable
capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a …

Cancers contain a suite of genetically stable cells within an extracellular matrix, collectively
termed the tumor microenvironment (TME). The TME strongly influences disease outcome …

Acute myeloid leukemia (AML) is a paradigmatic example of a stem cell-driven cancer. AML
belongs to the most aggressive malignancies and has a poor prognosis. A hallmark of AML …

Pediatric acute myeloid leukemia (pAML) is characterized by heterogeneous cellular
composition, driver alterations and prognosis. Characterization of this heterogeneity and …

Mitochondrial metabolism recently emerged as a critical dependency in acute myeloid
leukemia (AML). The shape of mitochondria is tightly regulated by dynamin GTPase …

Neutrophils are the most abundant leukocyte in humans and provide a critical early line of
defense as part of our innate immune system. We perform a comprehensive, genome-wide …

Leukemia is a type of clonal disorders of hematopoietic stem and progenitor cells
characterized by bone marrow failure, differentiation arrest, and lineage skewing. Despite …

Differentiation therapy using small molecules is a promising strategy for improving the
prognosis of glioblastoma (GBM). Histone acetylation plays an important role in cell fate …

Leukemic-stem-cell-specific targeting may improve the survival of patients with acute
myeloid leukemia (AML) by avoiding the ablative effects of standard regimens on normal …

Acute myeloid leukemias (AML) are severe hematomalignancies with dismal prognosis. The
post-translational modification SUMOylation plays key roles in leukemogenesis and AML …