▪ Abstract Toxic shock syndrome (TSS) is an acute onset illness characterized by fever, rash
formation, and hypotension that can lead to multiple organ failure and lethal shock, as well …

Superantigens (SAgs) are the most powerful T cell mitogens ever discovered.
Concentrations of less than 0· 1 pg/ml of a bacterial superantigen are sufficient to stimulate …

Recent work from several laboratories has demonstrated that proteolytic mechanisms
significantly contribute to the molecular interplay between Streptococcus pyogenes, an …

Necrotising fasciitis (NF) is situated with myositis and myonecrosis at the severe end of a
spectrum of skin and soft tissue infections but is far removed from erisepelas, impetigo and …

Antibacterials play a key role in the treatment of bone infections and appropriate surgical
prophylaxis. The rate and extent of penetration of antimicrobials into bone has been …

Necrotizing fasciitis (NF), a life-threatening rare infection of the soft tissues, is a medical and
surgical emergency. It is characterized by subtle, rapid onset of spreading inflammation and …

Skin and skin-structure infections are common, and range from minor pyodermas to severe
necrotizing infections. Complicated infections are defined as involving abnormal skin or …

Group A streptococcus (GAS) is a leading cause of severe, invasive human infections,
including necrotizing fasciitis and toxic shock syndrome. An important element of the …

Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both
antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria. They may …

Some isolates of the significant human pathogenStreptococcus pyogenes, including virulent
strains of the M1 serotype, secrete protein SIC. This molecule, secreted in large quantities …