In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …

The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

Newly generated excitatory synapses in the mammalian cortex lack sufficient AMPA-type
glutamate receptors to mediate neurotransmission, resulting in functionally silent synapses …

Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by
perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in …

Circular RNAs (circRNAs) are a newly appreciated class of RNAs expressed across diverse
phyla. These enigmatic transcripts are most commonly generated by back-splicing events …

Synthetic tissue-hydrogel methods have enabled superresolution investigation of biological
systems using diffraction-limited microscopy. However, chemical modification by fixatives …

Summary Synucleins (α, β, γ-synuclein) are a family of abundant presynaptic proteins. α-
Synuclein is causally linked to the pathogenesis of Parkinson's disease (PD). In an effort to …

Cells assemble macromolecular complexes into scaffoldings that serve as substrates for
catalytic processes. Years of molecular neurobiology research indicate that …

BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer
disease risk factor. Here, we investigate BIN1 function in the brain using conditional …

Calcium influx through voltage-gated Ca (CaV) channels is the first step in synaptic
transmission. This review concerns CaV channels at ribbon synapses in primary sense …