Oxidative stress (OS) is a chemical imbalance between an oxidant and an antioxidant,
causing damage to redox signaling and control or causing molecular damage. Unbalanced …

Extracellular vesicles (EVs) are kinds of two-layer vesicles secreted by cells. They play
significant roles in mediating component exchange between cells, signal transduction, and …

Widespread drug resistance has become the key issue in global healthcare. Extensive
efforts have been made to reveal not only diverse diseases experiencing drug resistance …

Extracellular vesicles (EVs), including exosomes, have an important role thanks to their
ability to communicate and exchange information between tumor cells and the tumor …

Silicosis is a devastating interstitial lung disease arising from long-term exposure to
inhalable silica. Regrettably, no therapy currently can effectively reverse the silica-induced …

Background: Acute myeloid leukaemia (AML) is the most common acute leukaemia in
adults; AML is highly heterogeneous and involves abnormalities at multiple omics levels …

Chimeric antigen receptor T-cell (CAR-T) therapy is a novel anticancer therapy using
autologous or allogeneic T-cells. To date, six CAR-T therapies for specific B-cell acute …

One contributor to the high mortality of osteosarcoma is its reduced sensitivity to
chemotherapy, but the mechanism involved is unclear. Improving the sensitivity of …

B-cell development is a very orchestrated pathway that involves several molecules, such as
transcription factors, cytokines, microRNAs, and also different cells. All these components …

Multidrug resistance is still a major obstacle to cancer treatment. The most studies are to
inhibit the activity of the drug transporter P-glycoprotein (P-gp), but the effect is not ideal …