Fluoroorganic chemistry has become essential in the evolution of many different but
interconnected research fields. These include the development of new materials with a …

All along the drug development process, one of the most frequent adverse side effects,
leading to the failure of drugs, is the cardiac arrhythmias. Such failure is mostly related to the …

The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

Since currently available antipsychotic medications predominantly treat hallucinations,
delusions, disorganized thoughts and behavior, and related agitation/aggression, attention …

The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation
and inhibition through the sodium-and chloride-dependent reuptake of glycine,–. Inhibition …

Over the last 20 years, glutamatergic models of schizophrenia have become increasingly
accepted as etiopathological models of schizophrenia, based on the observation that …

Amino acids are indispensable for the growth of cancer cells. This includes essential amino
acids, the carbon skeleton of which cannot be synthesized, and conditionally essential …

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

Importance In schizophrenia, the severity of negative symptoms is a key predictor of long-
term disability. Deficient signaling through theN-methyl-D-aspartate receptor is hypothesized …