Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

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The TDP-43 type C pathological form of frontotemporal lobar degeneration is characterized
by the presence of immunoreactive TDP-43 short and long dystrophic neurites, neuronal …

Progranulin (PGRN) is a protein encoded by the GRN gene with multiple identified functions
including as a neurotrophic factor, tumorigenic growth factor, anti-inflammatory cytokine and …

The aim of the present study was to examine the roles of l-fucose and the
glycosaminoglycans (GAGs) keratan sulfate (KS) and chondroitin sulfate/dermatan sulfate …

Disruption of colonic homeostasis caused by aberrant M1/M2 macrophage polarization
contributes to the development of inflammatory bowel disease (IBD). Lycium barbarum …

TAR DNA-binding protein 43 (TDP-43) has emerged as a key player in many
neurodegenerative pathologies, including frontotemporal lobar degeneration (FTLD) and …

Cytoplasmic inclusions containing aberrant proteolytic fragments of TDP-43 are associated
with frontotemporal lobar degeneration (FTLD) and other related pathologies. In FTLD, TDP …

Traumatic brain injury (TBI) can be progressive and can lead to the development of a long‐
term complication termed chronic traumatic encephalopathy. The mechanisms underlying …

Macrophage polarization is closely related to inflammation development, yet how
macrophages are polarized remains unclear. In our study, the number of M1 macrophages …