Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …
The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives
Over the past three decades, the enhanced permeability and retention (EPR) effect has
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …
been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines …
Multifunctional graphdiyne–cerium oxide nanozymes facilitate microRNA delivery and attenuate tumor hypoxia for highly efficient radiotherapy of esophageal cancer
X Zhou, M You, F Wang, Z Wang, X Gao… - Advanced …, 2021 - Wiley Online Library
Radioresistance is an important challenge for clinical treatments. The main causes of
radioresistance include hypoxia in the tumor microenvironment, the antioxidant system …
radioresistance include hypoxia in the tumor microenvironment, the antioxidant system …
Recent advances in active targeting of nanomaterials for anticancer drug delivery
One of the challenges in cancer chemotherapy is the low target to non-target ratio of
therapeutic agents which incur severe adverse effect on the healthy tissues. In this regard …
therapeutic agents which incur severe adverse effect on the healthy tissues. In this regard …
[HTML][HTML] Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …
Acid‐activatable transmorphic peptide‐based nanomaterials for photodynamic therapy
Inspired by the dynamic morphology control of molecular assemblies in biological systems,
we have developed pH‐responsive transformable peptide‐based nanoparticles for …
we have developed pH‐responsive transformable peptide‐based nanoparticles for …
Histidine as a key modulator of molecular self-assembly: Peptide-based supramolecular materials inspired by biological systems
Histidine, a versatile proteinogenic amino acid, plays a broad range of roles in all living
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …
organisms and behaves as a key mediator of the interactions of biomolecules with inorganic …
Carbon nitride hollow theranostic nanoregulators executing laser-activatable water splitting for enhanced ultrasound/fluorescence imaging and cooperative …
The limited efficacy of “smart” nanotheranostic agents in eradicating tumors calls for the
development of highly desirable nanoagents with diagnostics and therapeutics. Herein, to …
development of highly desirable nanoagents with diagnostics and therapeutics. Herein, to …
The development and progress of nanomedicine for esophageal cancer diagnosis and treatment
X Li, L Chen, S Luan, J Zhou, X Xiao, Y Yang… - Seminars in cancer …, 2022 - Elsevier
Esophageal cancer (EC) is a common gastrointestinal malignancy with poor prognosis and
high mortality. Although combined therapeutic strategies have been developed, the 5-year …
high mortality. Although combined therapeutic strategies have been developed, the 5-year …
Approaches to improve macromolecule and nanoparticle accumulation in the tumor microenvironment by the enhanced permeability and retention effect
V Ejigah, O Owoseni, P Bataille-Backer, OD Ogundipe… - Polymers, 2022 - mdpi.com
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing
macromolecules deliver their payload selectively to solid tumors. An important driver of …
macromolecules deliver their payload selectively to solid tumors. An important driver of …