Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently
in species relevant for human consumption. Apart from the toxicity that these molecules can …

Background In the last years, several food alerts have identified high levels of pyrrolizidine
alkaloids (PAs) in a wide variety of food products, highlighting their occurrence as a …

Background The burden of the COVID-19 pandemic in Peru has led to people seeking
alternative treatments as preventives and treatment options such as medicinal plants. This …

Pyrrolizidine alkaloids (PAs) are heterocyclic secondary metabolites with a typical
pyrrolizidine motif predominantly produced by plants as defense chemicals against …

Herbs and dietary supplement-induced liver injury (HILI) is the leading cause of drug-
induced liver injury in China. Among different hepatotoxic herbs, the pyrrolizidine alkaloid …

Acute liver toxicity, specifically in the form of hepatic veno-occlusive disease (HVOD), is
known from reports on human poisonings following ingestions of 1, 2-unsaturated …

Pyrrolizidine alkaloids (PAs) and PA N-oxides are common phytotoxins produced by over
6000 plant species. Humans are frequently exposed to PAs via ingestion of PA-containing …

Sinusoidal obstruction syndrome (SOS) is characterized by damage to small hepatic vessels
affecting particularly sinusoidal endothelium. Damaged sinusoids can be associated with a …

In the last decade, interest in food and plant natural products (FPNPs) has been growing
due to their medical applications. Liquid chromatography-high-resolution mass spectrometry …

Saturated and unsaturated pyrrolizidine alkaloids (PAs) are present in more than 6000 plant
species growing in countries all over the world. They have a typical heterocyclic structure in …