We previously demonstrated that intra-arterial infusion of insulin attenuates vasoreactivity to
phenylephrine and angiotensin II in the forearm of normotensive humans, which suggests …

Endothelial cells contain an enzyme (s) which produces nitric oxide from L-arginine in
response to a variety of mechanical stimuli as well as to autacoids and local and circulating …

The endothelium makes a significant contribution to the regulation of vascular tone through
the release of potent vasodilator agents such as nitric oxide (NO) and prostacyclin (PGI2) as …

This chapter summarizes concepts regarding the effects of hypertension on the cerebral
circulation. In relation to end-organ effects, the brain is one of the organs most significantly …

Background and Purpose Because tonic production of nitric oxide (NO) is important in
regulating cerebrovascular tone and NO may be important in the mechanism of brain injury …

Wistar-Furth rats have been shown to be resistant to mineralocorticoid-salt hypertension, but
the mechanism for this resistance is unknown. In the current experiments, adult male Wistar …

The contractile effects of 5‐hydroxytryptamine (5‐HT) in isolated ring preparations of basilar
arteries (BA), thoracic aortas (TA) and superior mesenteric arteries (SMA) from stroke‐prone …

Endothelial dysfunction has been reported to be a feature of hypertension. We have
investigated the relative contributions of nitric oxide (NO) and the endothelium-derived …

The goal of this study was to determine whether responses of cerebral vessels to
intravascular administration of serotonin are altered in stroke-prone spontaneously …

ABSTRACT Background and Purpose. Previously, 30 untreated hyperten sive patients were
investigated by transcranial Doppler (TCD) monitoring during physical exercise, and …