Heat shock proteins (HSPs) are essential mediators of cellular homeostasis by maintaining
protein functionality and stability, and activating appropriate immune cells. HSP activity is …

Background Gemcitabine is a standard chemotherapeutic agent for patients suffering from
pancreatic cancer. However, the applied therapy is not effective due to the resistance of …

Molecular chaperones, especially 70 kDa heat shock protein, in addition to their intracellular
localization in cancer cells, can be exposed on the surface of the plasma membrane. We …

Cholangiocarcinoma (CCA) is a prevalent cancer in Southeast Asia, with Opisthorchis
viverrini (O. viverrini) infection being the primary risk factor. Most CCA cases in this region …

新生多肽链通常需要折叠成独特的三维结构来发挥其生物学功能. 天然存在的蛋白质仅具有边缘
稳定性, 少量突变或轻微环境扰动就可能影响蛋白质的正确折叠. 蛋白质组的稳定性 …

Background: SCARA5 may play an important role in nasopharyngeal carcinoma. Materials &
methods: PCR and immunohistochemistry were used to detect the expression and promoter …

Native proteins are only marginally stable. Therefore, a few mutations or slight perturbation
in the environment could easily destroy their functional structures, causing them to misfold or …

Exosomal heat shock proteins (Hsps) are involved in intercellular communication both in
physiological and pathological conditions. They play a role in key processes of …

Background/Aim: From the standpoint of cancer therapy, it is valuable to enhance the
anticancer effects of chemotherapy. Our previous reports revealed that up-regulation of heat …

Abstract Heat-shock proteins (HSPs), one of the evolutionarily conserved protein families,
are widely found in various organisms, and play important physiological functions …