Integrated metabolomic–genomic workflows accelerate microbial natural product discovery

NE Avalon, AE Murray, BJ Baker - Analytical chemistry, 2022 - ACS Publications
The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …

Reading and surviving the harsh conditions in desert biological soil crust: the cyanobacterial viewpoint

HF Xu, H Raanan, GZ Dai, N Oren… - FEMS Microbiology …, 2021 - academic.oup.com
Biological soil crusts (BSCs) are found in drylands, cover∼ 12% of the Earth's surface in arid
and semi-arid lands and their destruction is considered an important promoter of …

Identification, Heterologous Expression, and Characterization of the Tolypodiol Biosynthetic Gene Cluster through an Integrated Approach

D Back, TJ O'Donnell, KK Axt, JR Gurr… - ACS Chemical …, 2023 - ACS Publications
Cyanobacteria are tremendous producers of biologically active natural products, including
the potent anti-inflammatory compound tolypodiol. However, linking biosynthetic gene …

[HTML][HTML] SEVA-Cpf1, a CRISPR-Cas12a vector for genome editing in cyanobacteria

S Baldanta, G Guevara, JM Navarro-Llorens - Microbial cell factories, 2022 - Springer
Background Cyanobacteria are photosynthetic autotrophs that have tremendous potential
for fundamental research and industrial applications due to their high metabolic plasticity …

Cyanobacterial secondary metabolites towards improved commercial significance through multiomics approaches

S Verma, S Thapa, N Siddiqui, H Chakdar - World Journal of Microbiology …, 2022 - Springer
Cyanobacteria are ubiquitous photosynthetic prokaryotes responsible for the oxygenation of
the earth's reducing atmosphere. Apart from oxygen they are producers of a myriad of …

[HTML][HTML] Harnessing the potential: advances in cyanobacterial natural product research and biotechnology

M Baunach, A Guljamow, M Miguel-Gordo… - Natural Product …, 2024 - pubs.rsc.org
Covering: 2000 to 2023Cyanobacteria produce a variety of bioactive natural products that
can pose a threat to humans and animals as environmental toxins, but also have potential …

[HTML][HTML] A multi-omics characterization of the natural product potential of tropical filamentous marine cyanobacteria

T Leão, M Wang, N Moss, R da Silva, J Sanders… - Marine drugs, 2021 - mdpi.com
Microbial natural products are important for the understanding of microbial interactions,
chemical defense and communication, and have also served as an inspirational source for …

[HTML][HTML] Recent advances in the heterologous expression of biosynthetic gene clusters for marine natural products

Y Xu, X Du, X Yu, Q Jiang, K Zheng, J Xu, P Wang - Marine Drugs, 2022 - mdpi.com
Marine natural products (MNPs) are an important source of biologically active metabolites,
particularly for therapeutic agent development after terrestrial plants and nonmarine …

[HTML][HTML] Characterization of a cyanobacterial rep protein with broad-host range and its utilization for expression vectors

Y Sakamaki, K Maeda, K Nimura-Matsune… - Frontiers in …, 2023 - frontiersin.org
Owing to their photosynthetic capabilities, cyanobacteria are regarded as ecologically
friendly hosts for production of biomaterials. However, compared to other bacteria, tools for …

Exploring cyanobacterial diversity for sustainable biotechnology

TT Selão - Journal of Experimental Botany, 2022 - academic.oup.com
Cyanobacteria are an evolutionarily ancient and diverse group of microorganisms. Their
genetic diversity has allowed them to occupy and play vital roles in a wide range of …