The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular response to
hypoxia and its expression levels are tightly controlled through synthesis and degradation. It …

Cells adapt to hypoxia by a cellular response, where hypoxia-inducible factor 1α (HIF-1α)
becomes stabilized and directly activates transcription of downstream genes. In addition to …

Background: Excessive production of mitochondrial reactive oxygen species (ROS) is a
central mechanism for the development of diabetes complications. Recently, hypoxia has …

The transcription factor complex hypoxia-inducible factor (HIF)-1 controls the expression of
most genes involved in adaptation to hypoxic conditions. HIF-1 is a heterodimer composed …

Abstract Bortezomib (PS-341), a proteasome inhibitor, has been examined clinically for the
treatment of multiple myeloma and several solid tumors. Bortezomib directly induces tumor …

Mutations in RPGRIP1L result in severe human diseases called ciliopathies. To unravel the
molecular function of RPGRIP1L, we analyzed Rpgrip1l−/− mouse embryos, which display a …

HIF-1α is overexpressed in many human cancers compared to normal tissues due to the
interaction of a multiplicity of factors and pathways that reflect specific genetic alterations …

Diabetic foot ulcerations (DFUs) represent a major medical, social, and economic problem.
Therapeutic options are restricted due to a poor understanding of the pathogenic …

Background The G protein estrogen receptor GPER/GPR30 mediates estrogen action in
breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key …

The success of pancreatic β-cells transplantation to treat type 1 diabetes has been hindered
by massive β-cell dysfunction and loss of β-cells that follows the procedure. Hypoxia …