Hypoxia-inducible factor 1α (HIF1α) is a critical transcriptional factor for inducing tumor
metastasis, and stabilized under hypoxia but degraded by von Hippel–Lindau protein …

Mouse mammary gland involution resembles a wound healing response with suppressed
inflammation. Wound healing and inflammation are also associated with tumour …

The abundance of the transcription factor hypoxia-inducible factor is regulated through
hydroxylation of its α-subunits by a family of prolyl-hydroxylases (PHD1–3). Enzymatic …

T helper 17 (TH17) cells are involved in several autoimmune diseases such as multiple
sclerosis (MS) and rheumatoid arthritis (RA). In addition to retinoic acid receptor-related …

Introduction Pyramidal (glutamatergic) neurons and interneurons are morphologically and
functionally well defined in the central nervous system. Although it is known that …

Hypoxia-inducible factor-1 alpha subunit (HIF-1α) is a transcriptional activator mediating
adaptive cellular response to hypoxia. Normally degraded in most cell types and tissues, HIF …

Hes1 is a Notch target gene that plays a major role during embryonic development. Previous
studies have shown that HIF-1α can interact with the Notch intracellular domain and …

In this study, we investigated the role of prostaglandin F2α (PGF2α) in mouse osteoblast
survival and the function of fibroblast growth factor 2 (FGF‐2) and fibroblast growth factor …

Up to date, the morbidity and mortality rates of acute lung injury (ALI) still rank high among
clinical illnesses. Endotoxin, also called lipopolysaccharide (LPS), induced sepsis is the …

Objectives The most frequent genomic abnormality in clear cell renal cell carcinoma (cc-
RCC) is inactivation of Von Hippel-Lindau gene (VHL). pVHL19 is a ligase promoting …