The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Impact of intermittent fasting on health and disease processes

MP Mattson, VD Longo, M Harvie - Ageing research reviews, 2017 - Elsevier
Humans in modern societies typically consume food at least three times daily, while
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …

Intermittent metabolic switching, neuroplasticity and brain health

MP Mattson, K Moehl, N Ghena… - Nature Reviews …, 2018 - nature.com
During evolution, individuals whose brains and bodies functioned well in a fasted state were
successful in acquiring food, enabling their survival and reproduction. With fasting and …

[HTML][HTML] The effects of intermittent fasting on brain and cognitive function

J Gudden, A Arias Vasquez, M Bloemendaal - Nutrients, 2021 - mdpi.com
The importance of diet and the gut-brain axis for brain health and cognitive function is
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …

[HTML][HTML] Brain insulin resistance and hippocampal plasticity: mechanisms and biomarkers of cognitive decline

M Spinelli, S Fusco, C Grassi - Frontiers in neuroscience, 2019 - frontiersin.org
In the last decade, much attention has been devoted to the effects of nutrient-related signals
on brain development and cognitive functions. A turning point was the discovery that brain …

The role of oxidative stress in Parkinson's disease

V Dias, E Junn, MM Mouradian - Journal of Parkinson's …, 2013 - content.iospress.com
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

AH Nagahara, MH Tuszynski - Nature reviews Drug discovery, 2011 - nature.com
The growth factor brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase receptor type B (TRKB) are actively produced and trafficked in multiple …

An affective neuroscience model of boosting resilience in adults

G Tabibnia - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Although research has identified dozens of behavioral and psychosocial strategies for
boosting resilience in adults, little is known about the common underlying pathways. A …

[PDF][PDF] Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

MP Mattson - Cell metabolism, 2012 - cell.com
Evolution favored individuals with superior cognitive and physical abilities under conditions
of limited food sources, and brain function can therefore be optimized by intermittent dietary …

Brain-derived neurotrophic factor in neurodegenerative diseases

C Zuccato, E Cattaneo - Nature Reviews Neurology, 2009 - nature.com
Abstract Changes in the levels and activities of neurotrophic factors, such as brain-derived
neurotrophic factor (BDNF), have been described in a number of neurodegenerative …