Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide.
However, there still remains a lack of effective diagnostic and therapeutic targets for this …

UFMylation involves the covalent modification of substrate proteins with UFM1 (Ubiquitin‐
fold modifier 1) and is important for maintaining ER homeostasis. Stalled translation triggers …

In plants, the endomembrane system is tightly regulated in response to environmental
stresses for maintaining cellular homeostasis. Autophagosomes, the double membrane …

Post-translational modifications (PTMs) add a major degree of complexity to the proteome
and are essential controllers of protein homeostasis. Amongst the hundreds of PTMs …

Summary Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …

Protein UFMylation, ie, post‐translational modification with ubiquitin‐fold modifier 1 (UFM1),
is essential for cellular and endoplasmic reticulum homeostasis. Despite its biological …

The stabilization of stalled forks has emerged as a crucial mechanism driving resistance to
poly (ADP-ribose) polymerase (PARP) inhibitors in BRCA1/2-deficient tumors. Here, we …

Chemoresistance is the main obstacle in osteosarcoma (OS) treatment; however, the
underlying mechanism remains unclear. In this study, it is discovered that DDRGK domain …