Cancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery

F Davodabadi, SF Sajjadi, M Sarhadi… - European Journal of …, 2023 - Elsevier
Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

[HTML][HTML] Cytokines in cancer drug resistance: Cues to new therapeutic strategies

VS Jones, RY Huang, LP Chen, ZS Chen, L Fu… - … et Biophysica Acta (BBA …, 2016 - Elsevier
The development of oncoprotein-targeted anticancer drugs is an invaluable weapon in the
war against cancer. However, cancers do not give up without a fight. They may develop …

Dual‐Locking nanoparticles disrupt the PD‐1/PD‐L1 pathway for efficient cancer immunotherapy

Z Zhang, Q Wang, Q Liu, Y Zheng, C Zheng… - Advanced …, 2019 - Wiley Online Library
The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated
(Cas) enzyme, Cas13a, holds great promise in cancer treatment due to its potential for …

Wharton jelly-derived mesenchymal stem cell exosomes induce apoptosis and suppress EMT signaling in cervical cancer cells as an effective drug carrier system of …

BI Abas, GM Demirbolat, O Cevik - PloS one, 2022 - journals.plos.org
Mesenchymal stem cells can be obtained and multiplied from various sources and have a
very high capacity to release exosomes. Exosomes are nano-sized extracellular vesicles …

Advances in mesoporous silica-based nanocarriers for co-delivery and combination therapy against cancer

RR Castillo, M Colilla, M Vallet-Regí - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: Nanocarriers have emerged as a powerful alternative for cancer therapy.
Indeed, they are promising candidates to tackle the acquired resistance of surviving cells …

Mechanisms of drug resistance in ovarian cancer and associated gene targets

KL Alatise, S Gardner, A Alexander-Bryant - Cancers, 2022 - mdpi.com
Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

DNA damage response and resistance of cancer stem cells

E Abad, D Graifer, A Lyakhovich - Cancer Letters, 2020 - Elsevier
The cancer stem cell (CSC) model defines tumors as hierarchically organized entities,
containing a small population of tumorigenic CSC, or tumour-initiating cells, placed at the …

Assessment of anticancer, antimicrobial, antidiabetic, anti-obesity and antioxidant activity of Ocimum Basilicum seeds essential oil from Palestine

AM Eid, N Jaradat, N Shraim, M Hawash, L Issa… - … Medicine and Therapies, 2023 - Springer
Background Many modern pharmaceutical researchers continue to focus on the discovery
and evaluation of natural compounds for possible therapies for obesity, diabetes, infections …

Novel delivery approaches for cancer therapeutics

AK Mitra, V Agrahari, A Mandal, K Cholkar… - Journal of controlled …, 2015 - Elsevier
Currently, a majority of cancer treatment strategies are based on the removal of tumor mass
mainly by surgery. Chemical and physical treatments such as chemo-and radiotherapies …

Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells

D Alimbetov, S Askarova, B Umbayev, T Davis… - International journal of …, 2018 - mdpi.com
Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they
tend to actively proliferate more than normal cells. They have well-known side-effects …