In recent years, suppressing tubulin polymerization has been developed as a therapeutic
approach for cancer treatment. Thus, new derivatives based on thiazol-5 (4H)-ones have …

Cancer cells usually show adaptations to their metabolism that facilitate their growth,
invasiveness, and metastasis. Therefore, reprogramming the energy metabolism is one of …

Simple Summary Metronomic chemotherapy, a continuous administration of a lowered dose
of drugs without long breaks, is currently considered an alternative approach for the …

Drug resistance is a major problem in cancer therapy. A growing body of evidence
demonstrates that the tumor microenvironment, including cancer-associated fibroblasts …

Breast cancer is the second leading cause of cancer-related death in women and is a
complex disease with high intratumoral and intertumoral heterogeneity. Such heterogeneity …

Ifosfamide (IFO) is a member of the oxazaphosphorine family of alkylating drugs that exhibits
anticancer and immunoregulatory properties. The toxicity of IFO is dose-limited because of …

Chalcones are precursors of flavonoids that exhibit structural heterogeneity and potential
antitumor activity. The objective of this study was to characterize the cytotoxicity of trans …

Background Drug resistance is a major obstacle to treating cancers because it desensitizes
cancer cells to chemotherapy. Recently, attention has been focused on changes in the tumor …

Localized drug-delivery systems (LDDSs) are a promising approach for cancer treatment
because they decrease systematic toxicity and enhance the therapeutic effect of the drugs …

The HOXA9 transcription factor serves as a molecular orchestrator in cancer stemness,
epithelial-mesenchymal transition (EMT), metastasis, and generation of the tumor …