Saga of Mcl-1: regulation from transcription to degradation

VV Senichkin, AY Streletskaia, AS Gorbunova… - Cell Death & …, 2020 - nature.com
The members of the Bcl-2 family are the central regulators of various cell death modalities.
Some of these proteins contribute to apoptosis, while others counteract this type of …

[HTML][HTML] Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications

H Tan, S Zhang, J Zhang, L Zhu, Y Chen, H Yang… - Theranostics, 2020 - ncbi.nlm.nih.gov
Gastric cancer (GC) is currently the fourth most common malignancy and the third leading
cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) …

Long noncoding RNA LINC00239 inhibits ferroptosis in colorectal cancer by binding to Keap1 to stabilize Nrf2

Y Han, X Gao, N Wu, Y Jin, H Zhou, W Wang… - Cell death & …, 2022 - nature.com
Ferroptosis, a novel regulated cell death induced by iron-dependent lipid peroxidation, plays
an important role in tumor development and drug resistance. Long noncoding RNAs …

Exosome-transferred LINC01559 promotes the progression of gastric cancer via PI3K/AKT signaling pathway

L Wang, X Bo, X Yi, X Xiao, Q Zheng, L Ma, B Li - Cell death & disease, 2020 - nature.com
Increasing evidence indicates that long non-coding RNAs (lncRNAs) are associated with the
progression of human cancers. However, the expression level and function of LINC01559 …

Roles of ncRNAs as ceRNAs in Gastric Cancer

J Ye, J Li, P Zhao - Genes, 2021 - mdpi.com
Although ignored in the past, with the recent deepening of research, significant progress has
been made in the field of non-coding RNAs (ncRNAs). Accumulating evidence has revealed …

Comprehensive analysis of necroptosis-related long noncoding RNA immune infiltration and prediction of prognosis in patients with colon cancer

L Liu, L Huang, W Chen, G Zhang, Y Li… - Frontiers in molecular …, 2022 - frontiersin.org
Colon cancer (CC) is one of the most frequent malignancies in the world, with a high rate of
morbidity and death. In CC, necroptosis and long noncoding RNA (lncRNAs) are crucial, but …

Research progress on the circRNA/lncRNA-miRNA-mRNA axis in gastric cancer

X Zeng, J Xiao, X Bai, Y Liu, M Zhang, J Liu… - … -Research and Practice, 2022 - Elsevier
Gastric cancer is one of the most common malignant tumours worldwide. Genetic and
epigenetic alterations are key factors in gastric carcinogenesis and drug resistance to …

A ceRNA network and a potential regulatory axis in gastric cancer with different degrees of immune cell infiltration

K Zhang, L Zhang, Y Mi, YC Tang, FF Ren… - Cancer …, 2020 - Wiley Online Library
Immune cell infiltration is an important indicator of whether tumor patients will benefit from
immunotherapy. Gastric cancer is one of the most common tumors in the world, and new …

Autophagy and gastrointestinal cancers: the behind the scenes role of long non-coding RNAs in initiation, progression, and treatment resistance

R Shafabakhsh, F Arianfar, M Vosough… - Cancer Gene …, 2021 - nature.com
Gastrointestinal (GI) cancers comprise a heterogeneous group of complex disorders that
affect different organs, including esophagus, stomach, gallbladder, liver, biliary tract …

Understanding MCL1: from cellular function and regulation to pharmacological inhibition

M Sancho, D Leiva, E Lucendo, M Orzáez - The FEBS Journal, 2022 - Wiley Online Library
Myeloid cell leukemia‐1 (MCL1), an antiapoptotic member of the BCL2 family characterized
by a short half‐life, functions as a rapid sensor that regulates cell death and other relevant …