Thrombosis is a major complication of cardiovascular disease, leading to myocardial
infarction, acute ischemic stroke, or venous thromboembolism. Thrombosis occurs when a …

Portal vein thrombosis (PVT) is a common complication among patients with cirrhosis.
However, its pathophysiology is not well established and there are currently very few …

Clinical observations and accumulating laboratory evidence support a complex interplay
between coagulation, inflammation, innate immunity and fibrinolysis in venous …

Current treatments to prevent thrombosis, namely anticoagulants and platelets antagonists,
remain complicated by the persistent risk of bleeding. Improved therapeutic strategies that …

Morbidity and mortality from venous thromboembolism (VTE), which refers to deep vein
thrombosis and pulmonary embolism, have a substantial effect on the global burden of …

Introduction Venous thromboembolism (VTE) is a complex disease that aggregates in
families. Both acquired and genetic risk factors are important. Proper recognition and …

Abstract C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a
major negative regulator of several biological pathways, including the contact pathway of …

Background Vascular activation is characterized by increased proinflammatory, pro
thrombotic, and proadhesive signaling. Several chronic and acute conditions, including Bcr …

Events mediated by the P-selectin/PSGL-1 pathway play a critical role in the initiation and
propagation of venous thrombosis by facilitating the accumulation of leukocytes and …

Venous thromboembolism (VTE) is a pathology encompassing deep vein thrombosis (DVT)
and pulmonary embolism (PE) associated with high morbidity and mortality. Because …