High iron is a risk factor for type 2 diabetes mellitus (T2DM) and affects most of its cardinal
features: decreased insulin secretion, insulin resistance, and increased hepatic …

Iron is an essential mineral participating in different functions of the organism under
physiological conditions. Numerous biological processes, such as oxygen and lipid …

Iron is a crucial element for mammalian cells, considering its intervention in several
physiologic processes. Its homeostasis is finely regulated, and its alteration could be …

The ability of the body to maintain homeostasis requires constant communication between
the brain and peripheral tissues. Different organs produce signals, often in the form of …

Recent years have brought about new understandings regarding the pathogenesis of
anemia in sports. From hemodilution and redistribution considered to contribute to the so …

Iron is an essential nutrient, and individual iron status is determined by the regulation of iron
absorption, which is driven by iron requirements. Iron deficiency (ID) disproportionately …

Metals are redox-active substances that participate in central biological processes and may
be involved in a multitude of pathogenic events. However, considering the inconsistencies …

The gut microbiota acts as a symbiotic microecosystem that plays an indispensable role in
the regulation of a number of metabolic processes in the host by secreting secondary …

Cellular iron homeostasis and mitochondrial iron homeostasis are interdependent.
Mitochondria must import iron to form iron–sulfur clusters and heme, and to incorporate …

Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating
levels of acute-phase reactant hepcidin and adiposity-associated inflammation …