Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity …

M Šimon, Š Mikec, SS Atanur, J Konc, NM Morton… - Genes & genomics, 2024 - Springer
Background Analysing genomes of animal model organisms is widely used for
understanding the genetic basis of complex traits and diseases, such as obesity, for which …

[HTML][HTML] Ferritin, transferrin, and transferrin receptor in relation to metabolic obesity phenotypes: Findings from the China Health and Nutrition Survey

Z Ren, X Cao, C Li, J Zhang, X Li, P Song… - Frontiers in Public …, 2022 - frontiersin.org
Background This study aimed to explore the relationship between iron markers and
metabolic obesity phenotypes and the role of age. Methods Data were from the China …

Prevalence and Characteristics of Metabolic Hyperferritinemia in a Population-Based Central-European Cohort

S Gensluckner, B Wernly, F Koutny, G Strebinger… - Biomedicines, 2024 - mdpi.com
Background: Hyperferritinemia (HF) is a common finding and can be considered as
metabolic HF (MHF) in combination with metabolic diseases. The definition of MHF was …

A novel brick on the wall of non-alcoholic fatty liver disease (NAFLD): Nuclear receptor coactivator 4 (NCOA4)

M Ucdal, A Burus, B Celtikci, HY Balaban - Medical Hypotheses, 2023 - Elsevier
Dysmetabolic iron overload syndrome (DIOS) defines a moderate increase in body iron load
in the absence of an identifiable cause of iron excess, and one of its main target organs is …

Relationship Analysis of Inorganic Arsenic Exposure and Metabolic Syndrome Based on Propensity Score Matching in Xinjiang, China

Y Nie, C Wang, L Yang, Z Yang, Y Sun… - … and Obesity: Targets …, 2022 - Taylor & Francis
Purpose The role of inorganic arsenic (iAs) in the risk of metabolic syndrome (MetS) remains
unclear. This investigation focused on the effect of iAs exposure on MetS and whether the …

Metal homeostasis and exposure in distinct phenotypic subtypes of insulin resistance among children with obesity

Á González-Domínguez, M Millán-Martínez… - Nutrients, 2023 - mdpi.com
Background: Trace elements and heavy metals have proven pivotal roles in childhood
obesity and insulin resistance. However, growing evidence suggests that insulin resistance …

Sexually dimorphic metal alterations in childhood obesity are modulated by a complex interplay between inflammation, insulin, and sex hormones

Á González‐Domínguez, J Domínguez‐Riscart… - …, 2023 - Wiley Online Library
Although growing evidence points to a pivotal role of perturbed metal homeostasis in
childhood obesity, sexual dimorphisms in this association have rarely been investigated. In …

Transferrin Saturation, Serum Ferritin, and C-Reactive Protein vs. Serum Ferritin for an optimal Iron Deficiency Diagnosis in Candidates for Bariatric Surgery

M Muñoz, ZPB Ramirez, ELM Rodriguez, JDR Blandón… - Obesity Surgery, 2024 - Springer
Materials and Methods We present a cross-sectional, analytical, and retrospective study,
evaluating the diagnostic tests in 96 patients, to whom two methods were applied for the …

Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice

J Wang, S Zhang, L Hu, Y Wang, K Liu, J Le… - Cell Death & …, 2023 - nature.com
Abnormal lipid metabolism and chronic low-grade inflammation are the main traits of
obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis …

Lycopene alleviates ionic disturbances and anaemia by improving iron homeostasis, insulin sensitivity, and ATPases activities in obese female rats

EI Ugwor, AS James, FC Thomas, EO Adeyi, UH Uzoka… - Obesity Medicine, 2023 - Elsevier
Background We have previously demonstrated the efficacy of lycopene against
cardiovascular and neurological complications associated with obesity. However, its effect …