Ginseng has been used in China as a superior medicinal material for thousands of years
that can nourish the five internal organs, calm the mind and benefit wisdom. Due to its anti …

Background Depression, as a prevalent and debilitating psychiatric disease, severely
decreases the life quality of individuals and brings heavy burdens to the whole society …

In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …

Depression is a common mental illness, which is related to monoamine neurotransmitters
and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems …

Background Depression is one of the most debilitating and severe psychiatric disorders and
a serious public health concern. Currently, many treatments are indicated for depression …

Melatonin, the major regulator of the sleep/wake cycle, also plays important physiological
and pharmacological roles in the control of neuronal plasticity and neuroprotection …

Introduction Major depressive disorder remains a prevalent world-wide health problem.
Currently available antidepressant medications take weeks of dosing, do not produce …

Major depressive disorder (MDD) is a leading chronic mental illness worldwide,
characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43) …

Major depressive disorder (MDD) is a severe mental disorder associated with high rates of
morbidity and mortality. Current first‐line pharmacotherapies for MDD are based on …

Background Insomnia and depressive disorder are two common symptoms with a reciprocal
causal relationship in clinical practice, which are usually manifested in comorbid form …