Computational protein engineering has enabled the rational design of customized proteins,
which has propelled both sequence-based and structure-based immunogen engineering …

We use computational design coupled with experimental characterization to systematically
investigate the design principles for macrocycle membrane permeability and oral …

Glycan masking is a novel technique in reverse vaccinology in which sugar chains (glycans)
are added on the surface of immunogen candidates to hide regions of low interest and thus …

Protein nanoparticle scaffolds are increasingly used in next-generation vaccine designs,
and several have established records of clinical safety and efficacy. Yet the rules for how …

Nanoparticle (NP) vaccine formulations promote immune responses through multiple
mechanisms. We recently reported that mannose-binding lectin (MBL) triggers trafficking of …

Targeted intracellular delivery via receptor‐mediated endocytosis requires the delivered
cargo to escape the endosome to prevent lysosomal degradation. This can in principle be …

Post-translational modifications (PTMs) of proteins play a vital role in their function and
stability. These modifications influence protein folding, signaling, protein-protein …

Computational protein sequence design has the ambitious goal of modifying existing or
creating new proteins; however, designing stable and functional proteins is challenging …

Each year vast international resources are wasted on irreproducible research. The scientific
community has been slow to adopt standard software engineering practices, despite the …

TGFβs, BMPs and Activins regulate numerous developmental and homeostatic processes
and signal through hetero-tetrameric receptor complexes composed of two types of …