In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …

It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

Full-grown oocytes are transcriptionally silent and must stably maintain the messenger
RNAs (mRNAs) needed for oocyte meiotic maturation and early embryonic development …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Reactive oxygen species (ROS) are mainly produced in mitochondria and are involved in
various physiological activities of the ovary through signaling and are critical for regulating …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …

Melatonin, mostly released by the pineal gland, is a circadian rhythm-regulated and
multifunctional hormone. Great advances in melatonin research have been made, including …

The ovarian system comprises vital organs in females and is of great significance for the
maintenance of reproductive potential and endocrine stability. Although complex …

In mammalian ovaries, oocytes are physically coupled to somatic granulosa cells, and this
coupling is crucial for the growth and development of competent oocytes as it mediates the …