RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

Microbiota–host communications: Bacterial extracellular vesicles as a common language

RA Ñahui Palomino, C Vanpouille, PE Costantini… - PLoS …, 2021 - journals.plos.org
Both gram-negative and gram-positive bacteria release extracellular vesicles (EVs) that
contain components from their mother cells. Bacterial EVs are similar in size to mammalian …

Extracellular vesicles—connecting kingdoms

E Woith, G Fuhrmann, MF Melzig - International journal of molecular …, 2019 - mdpi.com
It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

ZG Lu, J Shen, J Yang, JW Wang, RC Zhao… - … and Targeted Therapy, 2023 - nature.com
Nucleic acid drugs have the advantages of rich target selection, simple in design, good and
enduring effect. They have been demonstrated to have irreplaceable superiority in brain …

Immunoregulatory effects of stem cell-derived extracellular vesicles on immune cells

M Xie, W Xiong, Z She, Z Wen, AS Abdirahman… - Frontiers in …, 2020 - frontiersin.org
Recent investigations on the regulatory action of extracellular vesicles (EVs) on immune
cells in vitro and in vivo have sparked interest on the subject. As commonly known, EVs are …

Signal transduction pathways activated by innate immunity in mast cells: translating sensing of changes into specific responses

ZP Espinosa-Riquer, D Segura-Villalobos… - Cells, 2020 - mdpi.com
Mast cells (MCs) constitute an essential cell lineage that participates in innate and adaptive
immune responses and whose phenotype and function are influenced by tissue-specific …

Bacterial extracellular vesicles: A new way to decipher host‐microbiota communications in inflammatory dermatoses

MA Dagnelie, S Corvec, A Khammari… - Experimental …, 2020 - Wiley Online Library
Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, bearing
integral proteins and able to carry diverse cargo outside the cell to distant sites. In …

Extracellular vesicles as promising carriers in drug delivery: considerations from a cell biologist's perspective

G Pedrioli, E Piovesana, E Vacchi, C Balbi - Biology, 2021 - mdpi.com
Simple Summary Extracellular vesicles are promising nanocarriers of active pharmaceutical
ingredients in precision medicine. However, to develop safe and effective extracellular …

Synergic effects of decellularized bone matrix, hydroxyapatite, and extracellular vesicles on repairing of the rabbit mandibular bone defect model

A Emami, T Talaei-Khozani, S Tavanafar… - Journal of translational …, 2020 - Springer
Background Extracellular vesicles (ECV) and bone extracellular matrix (ECM) have
beneficial effects on the treatment of some pathological conditions. The purpose of this study …

The transformative impact of extracellular vesicles on developing sperm

MP Rimmer, CD Gregory… - Reproduction and …, 2021 - raf.bioscientifica.com
Objective To review the role of extracellular vesicles (EVs) released from the male
reproductive tract and their impact on developing sperm. We discuss how sperm exiting the …