Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update
CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19
genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor …
genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor …
Acute coronary syndromes
BA Bergmark, N Mathenge, PA Merlini… - The Lancet, 2022 - thelancet.com
Although substantial progress has been made in the diagnosis and treatment of acute
coronary syndromes, cardiovascular disease remains the leading cause of death globally …
coronary syndromes, cardiovascular disease remains the leading cause of death globally …
[HTML][HTML] Antiplatelet therapy after percutaneous coronary intervention
Antiplatelet therapy is key to reducing local thrombotic complications and systemic
ischaemic events among patients undergoing percutaneous coronary interventions (PCI) …
ischaemic events among patients undergoing percutaneous coronary interventions (PCI) …
Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (TALOS …
CJ Kim, MW Park, MC Kim, EH Choo, BH Hwang… - The Lancet, 2021 - thelancet.com
Background In patients with acute myocardial infarction receiving potent antiplatelet therapy,
the bleeding risk remains high during the maintenance phase. We sought data on a uniform …
the bleeding risk remains high during the maintenance phase. We sought data on a uniform …
[HTML][HTML] Clarifying the evidence on SARS-CoV-2 antigen rapid tests in public health responses to COVID-19
1 Collet JP, Thiele H, Barbato E, et al. 2020 ESC guidelines for the management of acute
coronary syndromes in patients presenting without persistent ST-segment elevation. Eur …
coronary syndromes in patients presenting without persistent ST-segment elevation. Eur …
Comparative effects of guided vs. potent P2Y12 inhibitor therapy in acute coronary syndrome: a network meta-analysis of 61 898 patients from 15 randomized trials
Aims Guidelines recommend the use of potent P2Y12 inhibitors over clopidogrel for the
reduction of ischaemic events in patients with acute coronary syndrome (ACS). However …
reduction of ischaemic events in patients with acute coronary syndrome (ACS). However …
Bleeding avoidance strategies in percutaneous coronary intervention
For many years, bleeding has been perceived as an unavoidable consequence of strategies
aimed at reducing thrombotic complications in patients undergoing percutaneous coronary …
aimed at reducing thrombotic complications in patients undergoing percutaneous coronary …
Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease
Multiple guidelines and consensus papers have addressed the role of antithrombotic
strategies in patients with established coronary artery disease (CAD). Since evidence and …
strategies in patients with established coronary artery disease (CAD). Since evidence and …
[HTML][HTML] Management of coronary artery disease in older adults: recent advances and gaps in evidence
Coronary artery disease (CAD) is highly prevalent in older adults, yet its management
remains challenging. Treatment choices are made complex by the frailty burden of older …
remains challenging. Treatment choices are made complex by the frailty burden of older …
CYP2C19 Genotype‐Guided Antiplatelet Therapy After Percutaneous Coronary Intervention in Diverse Clinical Settings
AL Beitelshees, CD Thomas, PE Empey… - Journal of the …, 2022 - Am Heart Assoc
Background Studies have demonstrated increased risk of major atherothrombotic events in
CYP2C19 loss‐of‐function (LOF) variant carriers versus non‐carriers treated with …
CYP2C19 loss‐of‐function (LOF) variant carriers versus non‐carriers treated with …