[HTML][HTML] RNA-binding proteins in tumor progression
H Qin, H Ni, Y Liu, Y Yuan, T Xi, X Li… - Journal of hematology & …, 2020 - Springer
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and
important biological functions. They are critical to maintain the transcriptome through post …
important biological functions. They are critical to maintain the transcriptome through post …
[HTML][HTML] MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
The p38 mitogen-activated protein kinase (p38MAPK) pathway has been implicated in a
variety of pathological conditions including inflammation and metastasis. Post-transcriptional …
variety of pathological conditions including inflammation and metastasis. Post-transcriptional …
[HTML][HTML] Systematic characterization of stress-induced RNA granulation
Upon stress, cytoplasmic mRNA is sequestered to insoluble ribonucleoprotein (RNP)
granules, such as the stress granule (SG). Partially due to the belief that translationally …
granules, such as the stress granule (SG). Partially due to the belief that translationally …
[HTML][HTML] Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways
X Meng, Y Zhao, B Han, C Zha, Y Zhang, Z Li… - Nature …, 2020 - nature.com
Activation of receptor tyrosine kinase (RTK) protein is frequently observed in malignant
progression of gliomas. In this study, the crosstalk activation of epidermal growth factor …
progression of gliomas. In this study, the crosstalk activation of epidermal growth factor …
[HTML][HTML] Emerging evidence of translational control by AU-rich element-binding proteins
H Otsuka, A Fukao, Y Funakami, KE Duncan… - Frontiers in …, 2019 - frontiersin.org
RNA-binding proteins (RBPs) are key regulators of posttranscriptional gene expression and
control many important biological processes including cell proliferation, development, and …
control many important biological processes including cell proliferation, development, and …
RNA-binding proteins in cancer drug discovery
JB Bertoldo, S Müller, S Hüttelmaier - Drug discovery today, 2023 - Elsevier
Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …
UPFront and center in RNA decay: UPF1 in nonsense-mediated mRNA decay and beyond
Nonsense-mediated mRNA decay (NMD), which is arguably the best-characterized
translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a …
translation-dependent regulatory pathway in mammals, selectively degrades mRNAs as a …
ARED-Plus: an updated and expanded database of AU-rich element-containing mRNAs and pre-mRNAs
Here we present an updated version of the AU-Rich Element Database (ARED-Plus) that is
freely available at http://brp. kfshrc. edu. sa/ared. AREs are conserved sequence elements …
freely available at http://brp. kfshrc. edu. sa/ared. AREs are conserved sequence elements …
[HTML][HTML] Identification of potential biomarkers related to glioma survival by gene expression profile analysis
JBK Hsu, TH Chang, GA Lee, TY Lee, CY Chen - BMC medical genomics, 2019 - Springer
Background Recent studies have proposed several gene signatures as biomarkers for
different grades of gliomas from various perspectives. However, most of these genes can …
different grades of gliomas from various perspectives. However, most of these genes can …
Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway
YC Lee, JT Chiou, LJ Wang, YJ Chen… - Toxicology and Applied …, 2023 - Elsevier
Accumulating evidence indicates that the anticancer activity of acridine derivatives is
mediated through the regulation of anti-apoptotic and pro-apoptotic BCL2 protein …
mediated through the regulation of anti-apoptotic and pro-apoptotic BCL2 protein …