Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

Pulmonary cryptococcosis: a review of pathobiology and clinical aspects

F Setianingrum, R Rautemaa-Richardson… - Medical …, 2019 - academic.oup.com
Pulmonary cryptococcosis is an important opportunistic invasive mycosis in
immunocompromised patients, but it is also increasingly seen in immunocompetent patients …

[HTML][HTML] Cryptococcus neoformans adapts to the host environment through TOR-mediated remodeling of phospholipid asymmetry

LC Ristow, AJ Jezewski, BJ Chadwick… - Nature …, 2023 - nature.com
Cryptococcus spp. are environmental fungi that first must adapt to the host environment
before they can cause life-threatening meningitis in immunocompromised patients. Host …

Global Molecular Epidemiology of Cryptococcus neoformans and Cryptococcus gattii: An Atlas of the Molecular Types

M Cogliati - Scientifica, 2013 - Wiley Online Library
Cryptococcosis is a fungal disease affecting more than one million people per year
worldwide. The main etiological agents of cryptococcosis are the two sibling species …

Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans

CA Desjardins, C Giamberardino, SM Sykes… - Genome …, 2017 - genome.cshlp.org
Cryptococcus neoformans is an opportunistic fungal pathogen that causes approximately
625,000 deaths per year from nervous system infections. Here, we leveraged a unique …

[HTML][HTML] Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review

MC Montoya, PM Magwene, JR Perfect - Journal of Fungi, 2021 - mdpi.com
The genus Cryptococcus contains two primary species complexes that are significant
opportunistic human fungal pathogens: C. neoformans and C. gattii. In humans …

A new lineage of Cryptococcus gattii (VGV) discovered in the Central Zambezian Miombo Woodlands

RA Farrer, M Chang, MJ Davis, L van Dorp, DH Yang… - MBio, 2019 - Am Soc Microbiol
We discovered a new lineage of the globally important fungal pathogen Cryptococcus gattii
on the basis of analysis of six isolates collected from three locations spanning the Central …

[HTML][HTML] The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

L Wang, B Zhai, X Lin - PLoS pathogens, 2012 - journals.plos.org
Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can
undergo morphotype transition between the yeast and the filamentous form and such …

Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans

KJ Boyce, Y Wang, S Verma, VPS Shakya, C Xue… - MBio, 2017 - Am Soc Microbiol
The ability to adapt to a changing environment provides a selective advantage to
microorganisms. In the case of many pathogens, a large change in their environment occurs …

[HTML][HTML] Infectious particle identity determines dissemination and disease outcome for the inhaled human fungal pathogen Cryptococcus

NM Walsh, MR Botts, AJ McDermott, SC Ortiz… - PLoS …, 2019 - journals.plos.org
The majority of invasive human fungal pathogens gain access to their human hosts via the
inhalation of spores from the environment into the lung, but relatively little is known about …