Co-evolution of immunity and seasonal influenza viruses
AX Han, SPJ de Jong, CA Russell - Nature Reviews Microbiology, 2023 - nature.com
Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …
escape host immunity. The viral constraints and host immune responses that limit and drive …
[HTML][HTML] Viral membrane fusion: a dance between proteins and lipids
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …
members of high concern for global human health. All enveloped viruses have a dedicated …
[HTML][HTML] Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids
JM Kastenschmidt, S Sureshchandra, A Jain… - Immunity, 2023 - cell.com
Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To
advance informed vaccine design, it is critical that we understand the cellular dynamics …
advance informed vaccine design, it is critical that we understand the cellular dynamics …
An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans
SF Andrews, LY Cominsky, GD Shimberg… - Science Translational …, 2023 - science.org
Current yearly seasonal influenza vaccines primarily induce an antibody response directed
against the immunodominant but continually diversifying hemagglutinin (HA) head region …
against the immunodominant but continually diversifying hemagglutinin (HA) head region …
Plasmonic nanostructure-enhanced Raman scattering for detection of SARS-CoV-2 nucleocapsid protein and spike protein variants
Epidemiological control and public health monitoring during the outbreaks of infectious viral
diseases rely on the ability to detect viral pathogens. Here we demonstrate a rapid …
diseases rely on the ability to detect viral pathogens. Here we demonstrate a rapid …
Breathing and tilting: mesoscale simulations illuminate influenza glycoprotein vulnerabilities
L Casalino, C Seitz, J Lederhofer… - ACS Central …, 2022 - ACS Publications
Influenza virus has resurfaced recently from inactivity during the early stages of the COVID-
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …
19 pandemic, raising serious concerns about the nature and magnitude of future epidemics …
[HTML][HTML] Functional antibodies exhibit light chain coherence
DB Jaffe, P Shahi, BA Adams, AM Chrisman… - Nature, 2022 - nature.com
The vertebrate adaptive immune system modifies the genome of individual B cells to encode
antibodies that bind particular antigens. In most mammals, antibodies are composed of …
antibodies that bind particular antigens. In most mammals, antibodies are composed of …
Principles and practical applications of structure-based vaccine design
PO Byrne, JS McLellan - Current opinion in immunology, 2022 - Elsevier
Highlights•Summary of the basic principles of structure-based vaccine design.•Review of
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …
Defining and studying B cell receptor and TCR interactions
CG Rappazzo, ML Fernández-Quintero… - The Journal of …, 2023 - journals.aai.org
Abstract BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …
which the adaptive immune system recognizes foreign and self-antigens, playing an integral …
The current state of research on influenza antiviral drug development: drugs in clinical trial and licensed drugs
Y Li, S Huo, Z Yin, Z Tian, F Huang, P Liu, Y Liu, F Yu - Mbio, 2023 - Am Soc Microbiol
Influenza viruses (IVs) threaten global human health due to the high morbidity, infection, and
mortality rates. Currently, the influenza drugs recommended by the FDA are oseltamivir …
mortality rates. Currently, the influenza drugs recommended by the FDA are oseltamivir …