Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …

Epidemiological data from the Center of Disease Control (CDC) and the World Health
Organization (WHO) statistics in 2017 show that 10.0 million people around the world …

For the successful treatment of pulmonary tuberculosis, drugs need to penetrate complex
lung lesions and permeate the mycobacterial cell wall in order to reach their intracellular …

The tuberculous granuloma is an elaborately organized structure and one of the main
histological hallmarks of tuberculosis. Macrophages, which are important immunologic …

A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …

Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …

Mathematical biology and pharmacology models have a long and rich history in the fields of
medicine and physiology, impacting our understanding of disease mechanisms and the …

In the 21st century, an array of microbiological and molecular allow antigens for new
vaccines to be specifically identified, designed, produced and delivered with the aim of …

Non‐human primates, primarily macaques, have been used to study tuberculosis for
decades. However, in the last 15 years, this model has been refined substantially to allow …

Monocyte lineage cells play important roles in health and disease. Their differentiation into
macrophages is crucial for a broad array of immunologic processes that regulate …