Epigenetics has transformed our understanding of the molecular basis of complex diseases,
including cardiovascular and metabolic disorders. This review offers a comprehensive …

Background Regular exercise reduces chronic disease risk and extends a healthy lifespan,
but the underlying molecular mechanisms remain unclear. DNA methylation is implicated in …

Background T2D is of high prevalence in the middle east and thus studying its mechanisms
is of a significant importance. Using 1026 Qatar BioBank samples, epigenetics, whole …

BACKGROUND: Despite advances in understanding hypertension's genetic structure, how
noncoding genetic variants influence it remains unclear. Studying their interaction with DNA …

Circadian rhythms integrate a finely tuned network of biological processes recurring every
24 h, intricately coordinating the machinery of all cells. This self-regulating system plays a …

Vascular dementia (VaD) is the second most common type of dementia. VaD is synonymous
with ageing, and its symptoms place a significant burden on the health and wellbeing of …

Objective DNA methylation influences gene expression and function in the pathophysiology
of type 2 diabetes mellitus (T2DM). Mapping of T2DM-associated DNA methylation could aid …

Background Intestinal metaplasia (IM) and intraepithelial neoplasia (IEN) are considered
precursors of gastric cardia cancer (GCC). Here, we investigated the histopathologic and …

Sex-based differences in the development of obesity-induced cardiometabolic dysfunction
are well documented, however, the specific mechanisms are not completely understood …

Background Heart failure (HF) is a disease that poses a serious threat to individual health,
and DNA methylation is an important mechanism in epigenetics, and its role in the …