[HTML][HTML] High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review

IJ Malesza, M Malesza, J Walkowiak, N Mussin… - Cells, 2021 - mdpi.com
The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …

[HTML][HTML] A comprehensive review of artificial intelligence and network based approaches to drug repurposing in Covid-19

F Ahmed, AM Soomro, ARC Salih… - Biomedicine & …, 2022 - Elsevier
Conventional drug discovery and development is tedious and time-taking process; because
of which it has failed to keep the required pace to mitigate threats and cater demands of viral …

Network medicine framework for identifying drug-repurposing opportunities for COVID-19

D Morselli Gysi, Í Do Valle, M Zitnik… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …

[HTML][HTML] Thyroid hormones interaction with immune response, inflammation and non-thyroidal illness syndrome

R De Luca, PJ Davis, HY Lin, F Gionfra… - Frontiers in cell and …, 2021 - frontiersin.org
The interdependence between thyroid hormones (THs), namely, thyroxine and
triiodothyronine, and immune system is nowadays well-recognized, although not yet fully …

[HTML][HTML] Gene co-expression in the interactome: moving from correlation toward causation via an integrated approach to disease module discovery

P Paci, G Fiscon, F Conte, RS Wang, L Farina… - NPJ systems biology …, 2021 - nature.com
In this study, we integrate the outcomes of co-expression network analysis with the human
interactome network to predict novel putative disease genes and modules. We first apply the …

[HTML][HTML] Recent advances in mass spectrometry-based computational metabolomics

TMD Ebbels, JJJ van der Hooft, H Chatelaine… - Current opinion in …, 2023 - Elsevier
The computational metabolomics field brings together computer scientists, bioinformaticians,
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …

IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis

M Kotlyar, C Pastrello, Z Ahmed, J Chee… - Nucleic acids …, 2022 - academic.oup.com
Improved bioassays have significantly increased the rate of identifying new protein-protein
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …

[HTML][HTML] Functional interaction among lncRNA HOTAIR and microRNAs in cancer and other human diseases

M Cantile, M Di Bonito, M Tracey De Bellis, G Botti - Cancers, 2021 - mdpi.com
Simple Summary This review aimed to describe the contribution of functional interaction
between the lncRNA HOTAIR and microRNAs in human diseases, including cancer …

Epigenetics and pulmonary diseases in the horizon of precision medicine: a review

G Benincasa, DL DeMeo, K Glass… - European …, 2021 - Eur Respiratory Soc
Epigenetic mechanisms represent potential molecular routes which could bridge the gap
between genetic background and environmental risk factors contributing to the …

[HTML][HTML] SAveRUNNER: A network-based algorithm for drug repurposing and its application to COVID-19

G Fiscon, F Conte, L Farina, P Paci - PLoS computational biology, 2021 - journals.plos.org
The novelty of new human coronavirus COVID-19/SARS-CoV-2 and the lack of effective
drugs and vaccines gave rise to a wide variety of strategies employed to fight this worldwide …