Background: Short-term heart rate variability (HRV) is most commonly attributed to
physiologic vagal tone modulation. However, with aging and cardiovascular disease, the …

Progressive fibrosis is a feature of aging and chronic tissue injury in multiple organs,
including the kidney and heart. Glioma-associated oncogene 1 expressing (Gli1+) cells are …

Cardiac scars, often dubbed 'dead tissue', are very much alive, with heterocellular activity
contributing to the maintenance of structural and mechanical integrity following heart injury …

Heart failure (HF) is a multifactorial disorder and is usually the end stage of many
cardiovascular diseases (CVD). HF presents one of the highest morbidity and mortality …

Aims The aim of our study was to establish normal ranges for left atrial (LA) strain and strain
rate using cardiac magnetic resonance feature tracking (CMR-FT), LA sphericity index, and …

Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients
hospitalized with heart failure, HFpEF is now as common as heart failure with reduced …

Cardiac regeneration, that is, restoration of the original structure and function in a damaged
heart, differs from tissue repair, in which collagen deposition and scar formation often lead to …

Overlapping risks for cancer and cardiovascular diseases (CVD), the two leading causes of
mortality worldwide, suggest a shared biology between these diseases. The role of …

Circulating proteomic signatures of age are closely associated with aging and age-related
diseases; however, the utility of changes in secreted proteins in identifying therapeutic …

Fibrosis is the abnormal accumulation of extracellular matrix proteins such as collagen and
fibronectin. Aging, injury, infections, and inflammation can cause different types of tissue …