Atrial fibrillation (AF) is the most common sustained arrhythmia in the population and is
associated with a significant clinical and economic burden. Rigorous assessment of the …

A chronic low-grade inflammation is one of the hallmarks of the aging process. This
gradually augmenting inflammatory state has been termed inflammaging. Inflammaging is …

Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged
cardiac metabolism and abnormal redox state during cardiac diseases foment …

Aging is characterized by functional decline in homeostatic regulation and vital cellular
events. This process can be linked with the development of cardiovascular diseases (CVDs) …

Late gadolinium enhancement is a useful tool for scar detection, based on differences in the
volume of distribution of gadolinium, an extracellular agent. The presence of fibrosis in the …

Caloric restriction has been associated with increased life span and reduced aging-related
disorders and reduces fibrosis in several diseases. Fibrosis is characterized by deposition of …

Aging, the main risk factor for cardiovascular disease (CVD), is becoming progressively
more prevalent in our societies. A better understanding of how aging promotes CVD is …

Heart disease causing cardiac cell death due to ischemia–reperfusion injury is a major
cause of morbidity and mortality in the United States. Coronary heart disease and …

The mineralocorticoid receptor (MR) was originally identified as a regulator of blood
pressure, able to modulate renal sodium handling in response to its principal ligand …

The cardiac extracellular matrix (ECM) provides the architectural scaffold to support efficient
contraction and relaxation of cardiomyocytes. The elegant design of the ECM facilitates …