Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Pyroptosis, a lytic pro-inflammatory type of programmed cell death, has been widely studied
in diverse inflammatory disease models. Membrane perforation and cell swelling induced by …

Abstract Sirtuin 3 (SIRT3) is a potential therapeutic target for cardiovascular, metabolic, and
other aging-related diseases. In this study, we investigated the role of SIRT3 in diabetic …

Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2
(TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which …

Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory
response, which is essential for the proper functioning of our immune system. When …

Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2
infection. In multivariate analysis, advanced age was an independent risk factor for death …

Inflammasome activation plays a crucial role in the progression to more severe stages of
non-alcoholic fatty liver disease (NAFLD), representing a promising therapeutic target …

In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …

Dementia remains an extremely prevalent syndrome among older people and represents a
major cause of disability and dependency. Alzheimer's disease (AD) accounts for the …

Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM)
and remains the leading cause of visual impairment in working-aged people. DR is related …