Human fear conditioning research since Watson's case study on “Little Albert” has vastly
evolved and its impact today is reaching far beyond phobic anxiety. This review focuses on …

Stress and pain are interleaved at multiple levels-interacting and influencing each other.
Both are modulated by psychosocial factors including fears, beliefs, and goals, and are …

Background We systematically reviewed all literature concerning online Acceptance and
Commitment Therapy (ACT) interventions for chronic pain to evaluate their (1) ACT …

Highlights•We reviewed recent developments in the fear of movement-related pain and
avoidance.•Learning is key to acquisition, generalization, and extinction of pain-related …

Treatment outcomes are strongly influenced by expectations, as evidenced by the placebo
effect. Meta-analyses of clinical trials reveal that placebo effects are strongest in pain …

Painful conditions are among the leading causes of years lived with disability, and may
increase following the coronavirus pandemic, which has led to temporary closure of some …

Chronic pain is a common and costly condition, and some people with chronic pain engage
in problematic opioid use. There is a critical need to identify factors underlying this co …

Chronic, or persistent pain affects more than 10% of adults in the general population. This
makes it one of the major physical and mental health care problems. Although pain is an …

All preclinical procedures for analgesic drug discovery involve two components: 1) a “pain
stimulus”(the principal independent variable), which is delivered to an experimental subject …

The formation and persistence of negative pain-related expectations by classical
conditioning remain incompletely understood. We elucidated behavioural and neural …