Conspectus Molecular association of proteins with nucleic acids is required for many
biological processes essential to life. Electrostatic interactions via ion pairs (salt bridges) of …

DNA dynamics can only be understood by taking into account its complex mechanical
behavior at different length scales. At the micrometer level, the mechanical properties of …

In the cell, DNA is arranged into highly-organised and topologically-constrained
(supercoiled) structures. It remains unclear how this supercoiling affects the detailed double …

By regulating access to the genetic code, DNA supercoiling strongly affects DNA
metabolism. Despite its importance, however, much about supercoiled DNA (positively …

To simulate long time and length scale processes involving DNA it is necessary to use a
coarse-grained description. Here we provide an overview of different approaches to such …

Based on soft‐touch atomic force microscopy, a method is described to reconstruct the
secondary structure of single extended biomolecules, without the need for crystallization …

Since 2000, some thirteen quinolones and fluoroquinolones have been developed and
have come to market. The quinolones, one of the most successful classes of antibacterial …

Antibiotics, long used in an attempt to solve the problem of bacterial infections, have resulted
in the unintended consequence of a worldwide spread of antibiotic resistance. The problem …

Thursday, February 25, 2021 221a sequences to superhelical apices. Base pair disruption
allows sharp bending at superhelical apices, which facilitates DNA writhing and, thus …

DNA in cells is organized in negatively supercoiled loops. The resulting torsional and
bending strain allows DNA to adopt a surprisingly wide variety of 3-D shapes. This interplay …