In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of
phospholipase A2 and the release of arachidonic acid (AA) from membrane phospholipids …

The use of non-steroidal anti-inflammatory drugs (NSAIDs) is widespread worldwide thanks
to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is …

Epidemiological data suggest that consumption of fruits and vegetables has been
associated with a lower incidence of cancer. Cyanidin-3-glucoside (C3G), a compound …

The 2-(2-arylphenyl) benzoxazole moiety has been found to be a new and selective ligand
for the enzyme cyclooxygenase-2 (COX-2). The 2-(2-arylphenyl) benzoxazoles 3a–m have …

Nonsteroidal anti-inflammatory drugs (NSAID) display promising antineoplastic activity for
colorectal and other cancers, but toxicity from COX inhibition limits their long-term use for …

Cyclooxygenase-2 is frequently overexpression in malignant tumors and the product PGE 2
promotes cancer cell progression and metastasis. We designed novel series of coumarin …

Isatin is a versatile compound with a diversity of effects. We designed to investigate the
inhibitory effect of isatin derivatives on lipopolysaccharide/interferon-γ-induced expression …

Celecoxib is an NSAID that was developed as a selective inhibitor of COX-2 and approved
by the FDA for the treatment of various forms of arthritis and the management of acute or …

While it has been established that both the constitutive and inducible forms of
cyclooxygenase (COX‐1 and COX‐2, respectively) play important roles in chemical initiation …

Nitric oxide (NO) a gaseous free radical is one of the ten smallest molecules found in nature,
while hydrogen sulfide (H 2 S) is a gas that bears the pungent smell of rotten eggs. Both are …