Simple Summary Protein phosphorylation is a key regulatory mechanism that controls a
wide variety of cellular responses. This process is catalysed by the members of the protein …

Early B cell development in the bone marrow ensures the replenishment of the peripheral B
cell pool. Immature B cells continuously develop from hematopoietic stem cells, in a process …

FMS-like tyrosine kinase 3 (FLT3) gene mutations have been found in more than one-third of
Acute Myeloid Leukemia (AML) cases. The most common point mutation in FLT3 occurs at …

Uncontrolled proliferative signals and cell cycle dysregulation due to genomic or functional
alterations are important drivers of the expansion of undifferentiated blast cells in acute …

FLT3 mutations are one of the most common genetic alterations in acute myeloid leukemia
(AML) and are identified in approximately one-third of newly diagnosed patients. Aberrant …

Fms‐like tyrosine kinase 3 (FLT3) is frequently mutated in haematological malignancies.
Although canonical FLT3 mutations including internal tandem duplications (ITDs) and …

The concept that different leukemias are developmentally distinct and, like in normal
hematopoiesis, generated by restricted populations of cells named leukemia-initiating cells …

Aim: The main goal of this study was to elucidate at the transcript level the tyrosine kinase
expression profiles of primary leukemia cells from mixed lineage leukemia 1 gene …

Background: Acute myeloid leukemia (AML) is the second most frequent leukemia in
childhood. The FLT3 gene participates in hematopoietic stem cell proliferation. FLT3 …

Background Fms-like tyrosine kinase 3 (FLT3) expression and mutation have been
considered a poor prognostic factor in acute myeloid leukemia (AML). FLT3-ITD mutation is …