Clinical and translational attributes of immune-related adverse events

KPM Suijkerbuijk, MJM van Eijs, F van Wijk… - Nature Cancer, 2024 - nature.com
With immune checkpoint inhibitors (ICIs) becoming the mainstay of treatment for many
cancers, managing their immune-related adverse events (irAEs) has become an important …

[HTML][HTML] Pulmonary toxicity of immune checkpoint immunotherapy

MI Ghanbar, K Suresh - The Journal of Clinical Investigation, 2024 - Am Soc Clin Investig
Cancer remains a leading cause of mortality on a global scale. Lung cancer, specifically non–
small cell lung cancer (NSCLC), is a prominent contributor to this burden. The management …

[HTML][HTML] Incidence, risk factors and outcomes of checkpoint inhibitor-induced liver injury: A 10-year real-world retrospective cohort study

E Atallah, SJ Welsh, B O'Carrigan, A Oshaughnessy… - JHEP Reports, 2023 - Elsevier
Abstract Background & Aims Checkpoint inhibitors (CPI) account for increasing numbers of
drug-induced liver injury (DILI) cases. We aimed to determine the incidence rate and risk …

Collaborative privacy-preserving analysis of oncological data using multiparty homomorphic encryption

R Geva, A Gusev, Y Polyakov, L Liram… - Proceedings of the …, 2023 - National Acad Sciences
Real-world healthcare data sharing is instrumental in constructing broader-based and larger
clinical datasets that may improve clinical decision-making research and outcomes …

Lung cancer in patients who have never smoked—An emerging disease

J LoPiccolo, A Gusev, DC Christiani… - Nature Reviews Clinical …, 2024 - nature.com
Lung cancer is the most common cause of cancer-related deaths globally. Although smoking-
related lung cancers continue to account for the majority of diagnoses, smoking rates have …

Immune‐related adverse events after immune check point inhibitors: Understanding the intersection with autoimmunity

N Singh, AM Hocking, JH Buckner - Immunological Reviews, 2023 - Wiley Online Library
Immune checkpoint inhibitor therapies act through blockade of inhibitory molecules involved
in the regulation of T cells, thus releasing tumor specific T cells to destroy their tumor targets …

Role of B cells in immune‐related adverse events following checkpoint blockade

KM Dhodapkar, A Duffy… - Immunological Reviews, 2023 - Wiley Online Library
Blockade of immune checkpoints has transformed the therapy of several cancers. However,
immune‐related adverse events (irAEs) have emerged as a major challenge limiting the …

Treatment-related adverse events, including fatal toxicities, in patients with solid tumours receiving neoadjuvant and adjuvant immune checkpoint blockade: a …

Y Fujiwara, N Horita, E Adib, S Zhou, AH Nassar… - The Lancet …, 2024 - thelancet.com
Background Incorporating immune checkpoint blockade into perioperative cancer therapy
has improved clinical outcomes. However, the safety of immune checkpoint blockade needs …

Update on biomarkers in renal cell carcinoma

RM Saliby, E Saad, S Kashima… - American Society of …, 2024 - ascopubs.org
Immune checkpoint inhibitors have significantly transformed the treatment paradigm for
metastatic renal cell carcinoma (RCC), offering prolonged overall survival and achieving …

Immune-related adverse events of immune checkpoint inhibitors

M Ramos-Casals, A Sisó-Almirall - Annals of Internal Medicine, 2024 - acpjournals.org
Immune-related adverse events (irAEs) are toxicities that arise after the administration of
monoclonal antibodies targeting immune checkpoints (immune checkpoint inhibitors [ICIs]) …