Moroccan antidiabetic medicinal plants: Ethnobotanical studies, phytochemical bioactive compounds, preclinical investigations, toxicological validations and clinical …

A Bouyahya, N El Omari, N Elmenyiy… - Trends in Food Science …, 2021 - Elsevier
Background Moroccan flora is rich with medicinal plants that are widely used in traditional
medicine for the treatment of various diseases including diabetes. These plants possess …

[HTML][HTML] Anti-inflammatory effects of thymoquinone and its protective effects against several diseases

Z Kohandel, T Farkhondeh, M Aschner… - Biomedicine & …, 2021 - Elsevier
Abstract Thymoquinone (TQ, 2-methyl-5-isopropyl-1, 4-benzoquinone), a monoterpene
molecule present in Nigella sativa L., has an anti-inflammatory, anti-oxidant, and anti …

[HTML][HTML] Antioxidant, Antidiabetic, and Antibacterial Potentials and Chemical Composition of Salvia officinalis and Mentha suaveolens Grown Wild in Morocco

SH Al-Mijalli, H Assaggaf, A Qasem… - Advances in …, 2022 - hindawi.com
This work evaluated in vitro antioxidant, antidiabetic, and antibacterial properties of Salvia
officinalis (S. officinalis) and Mentha suaveolens (M. suaveolens) essential oils (EO). The …

Cold plasma approach fortifies the topical application of thymoquinone intended for wound healing via up-regulating the levels of TGF-ß, VEGF, and α-SMA in rats

AA Sedik, M Salama, K Fathy, A Salama - International …, 2023 - Elsevier
Wound healing is a series of coordinated events that involve tissue repair and regeneration.
Cold atmospheric plasma approach sheds the light on the mechanism that initiates the …

Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats

İ Aktaş, F Mehmet Gür - Biotechnic & Histochemistry, 2022 - Taylor & Francis
We investigated the hepato-protective effects of thymoquinone (TQ) and beta-
aminoisobutyric acid (BAIBA). We used five groups of 8-week-old male rats: untreated …

Therapeutic perspective of thymoquinone: A mechanistic treatise

MS Butt, M Imran, A Imran, MS Arshad… - Food Science & …, 2021 - Wiley Online Library
The higher utilization of fruits and vegetables is well known to cure human maladies due to
the presence of bioactive components. Among these compounds, thymoquinone, a …

[HTML][HTML] Anticancer and anti-metastatic role of thymoquinone: Regulation of oncogenic signaling cascades by thymoquinone

AA Farooqi, R Attar, B Xu - International Journal of Molecular Sciences, 2022 - mdpi.com
Cancer is a life-threatening and multifaceted disease. Pioneering research works in the past
three decades have mechanistically disentangled intertwined signaling networks which play …

The ameliorative effects of thymoquinone and beta-aminoisobutyric acid on streptozotocin-induced diabetic cardiomyopathy

FM Gur, I Aktas - Tissue and Cell, 2021 - Elsevier
Diabetic cardiomyopathy (DCM) is a cardiac dysfunction observed in a patient with diabetes
that may lead to heart failure. No specific treatment has yet been tested in DCM. Therefore …

Exosomes from β-cells alleviated hyperglycemia and enhanced angiogenesis in islets of streptozotocin-induced diabetic mice

Y Sun, Q Mao, C Shen, C Wang… - … , Metabolic Syndrome and …, 2019 - Taylor & Francis
Purpose Exosomes are small nanoscale vesicles secreted from cells. Exosome-based
therapeutic approaches have been evaluated in treating ischemic diseases. In the present …

[HTML][HTML] Thymoquinone in ocular neurodegeneration: modulation of pathological mechanisms via multiple pathways

NM Mahmud, L Paraoan, N Khaliddin… - Frontiers in Cellular …, 2022 - frontiersin.org
Thymoquinone is a naturally occurring compound and is the major component of Nigella
sativa, also known as black seed or black cumin. For centuries thymoquinone has been …