Membrane-confined liquid-liquid phase separation toward artificial organelles
As the basic unit of life, cells are compartmentalized microreactors with molecularly crowded
microenvironments. The quest to understand the cell origin inspires the design of synthetic …
microenvironments. The quest to understand the cell origin inspires the design of synthetic …
Modulating liquid–liquid phase separation of FUS: mechanisms and strategies
Y Ji, F Li, Y Qiao - Journal of Materials Chemistry B, 2022 - pubs.rsc.org
Liquid–liquid phase separation (LLPS) of biomolecules inspires the construction of
protocells and drives the formation of cellular membraneless organelles. The resulting …
protocells and drives the formation of cellular membraneless organelles. The resulting …
Plant cell-inspired membranization of coacervate protocells with a structured polysaccharide layer
Y Ji, Y Lin, Y Qiao - Journal of the American Chemical Society, 2023 - ACS Publications
The design of compartmentalized colloids that exhibit biomimetic properties is providing
model systems for developing synthetic cell-like entities (protocells). Inspired by the cell …
model systems for developing synthetic cell-like entities (protocells). Inspired by the cell …
Spatiotemporal Dynamic Assembly/Disassembly of Organelle‐Mimics Based on Intrinsically Disordered Protein‐Polymer Conjugates
H Zhao, E Ibarboure, V Ibrahimova, Y Xiao… - Advanced …, 2021 - Wiley Online Library
Abstract Design of reversible organelle‐like microcompartments formed by liquid–liquid
phase separation in cell‐mimicking entities has significantly advanced the bottom‐up …
phase separation in cell‐mimicking entities has significantly advanced the bottom‐up …
Directing Transition of Synthetic Protocell Models via Physicochemical Cues‐Triggered Interfacial Dynamic Covalent Chemistry
Y Ji, W Mu, H Wu, Y Qiao - Advanced Science, 2021 - Wiley Online Library
As the preliminary synthetic analogs of living cells, protocells with life‐like features serve as
a versatile platform to explore the origin of life. Although protocells constructed from multiple …
a versatile platform to explore the origin of life. Although protocells constructed from multiple …
Manipulation of coacervate droplets with an electric field
Many biopolymers are highly charged, and as in the case of many polymer mixtures, they
tend to phase separate as a natural consequence of chain connectivity and an associated …
tend to phase separate as a natural consequence of chain connectivity and an associated …
Engineering the Spatial Distribution of Amphiphilic Molecule within Complex Coacervate Microdroplet via Modulating Charge Strength of Polyelectrolytes
The investigation of the interplay between complex coacervate microdroplets and
amphiphilic molecules offers valuable insights into the processes of prebiotic …
amphiphilic molecules offers valuable insights into the processes of prebiotic …
Regulating FUS Liquid-Liquid Phase Separation via Specific Metal Recognition
F Li, Y Lin, Y Qiao - Chinese Journal of Polymer Science, 2022 - Springer
Liquid-liquid phase separation (LLPS) or biomolecular condensation that leads to formation
of membraneless organelles plays a critical role in many biochemical processes …
of membraneless organelles plays a critical role in many biochemical processes …