Overcoming cancer chemotherapy resistance by the induction of ferroptosis

Y Wang, X Wu, Z Ren, Y Li, W Zou, J Chen… - Drug Resistance …, 2023 - Elsevier
Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically …

[HTML][HTML] Monomeric compounds from traditional Chinese medicine: New hopes for drug discovery in pulmonary fibrosis

Q Wang, W Li, H Hu, X Lu, S Qin - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Pulmonary fibrosis (PF) is a chronic and irreversible pulmonary disease, and can lead to
decreased lung function, respiratory failure and even death. The pathogenesis research and …

[HTML][HTML] Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy

F Khan, P Pandey, M Verma, S Ramniwas… - Biomedicine & …, 2024 - Elsevier
Ferroptosis, a novel form of regulated cell death characterized by dependence on iron and
lipid peroxidation, has been implicated in a wide range of clinical conditions including …

Synthesis of Ester‐Linked Ursolic Acid‐Based Hybrid Compounds: Potential Antibacterial and Anticancer Agents

V Khwaza, OO Oyedeji, SO Oselusi… - Chemistry & …, 2023 - Wiley Online Library
The molecular hybridization of two or more drugs into a single molecule is an effective drug
design approach to reduce pill burden and improve patient treatment adherence. Ursolic …

[HTML][HTML] Artesunate inhibits airway remodeling in asthma via the MAPK signaling pathway

M Zhang, J Lin, J Zhang, R Zhao, J Wan… - Frontiers in …, 2023 - frontiersin.org
Background: Artesunate (ART), is a semi-synthetic water-soluble artemisinin derivative
extracted from the plant Artemisia annua, which is often used to treating malaria. In vivo and …

[HTML][HTML] Advocacy for the Medicinal Plant Artabotrys hexapetalus (Yingzhao) and Antimalarial Yingzhaosu Endoperoxides

C Bailly, JP Hénichart - Molecules, 2022 - mdpi.com
The medicinal plant Artabotrys hexapetalus (synonyms: A. uncinatus and A. odoratissimus)
is known as yingzhao in Chinese. Extracts of the plant have long been used in Asian folk …

[HTML][HTML] Artesunate Exerts Organ-and Tissue-Protective Effects by Regulating Oxidative Stress, Inflammation, Autophagy, Apoptosis, and Fibrosis: A Review of …

M Zhu, Y Wang, J Han, Y Sun, S Wang, B Yang… - Antioxidants, 2024 - mdpi.com
The human body comprises numerous organs and tissues operating in synchrony, it
facilitates metabolism, circulation, and overall organismal function. Consequently, the well …

[HTML][HTML] Reduning alleviates sepsis-induced acute lung injury by reducing apoptosis of pulmonary microvascular endothelial cells

Z Wang, Z Guo, X Wang, H Liao, F Chen, Y Liu… - Frontiers in …, 2023 - frontiersin.org
Introduction Sepsis-induced acute lung injury (SALI) is a critical illness with high mortality,
and pulmonary microvascular endothelial cells (PMECs) barrier dysfunction is a well …

[HTML][HTML] Berberine-based self-assembly agents with enhanced synergistic antitumor efficacy

Y Wang, Z Li, H Zhang, P Wu, Y Zhao, R Li… - Frontiers in …, 2024 - frontiersin.org
Tumors are still a major threat to people worldwide. Nanodrug delivery and targeting
systems can significantly improve the therapeutic efficacy of chemotherapeutic drugs for …

Novel artesunate and isatin hybrid CT3-1 suppresses collagen-induced arthritis through abrogating dendritic cell chemotaxis-induced by CCR5

J He, X Lin, X Gao, H Luan, Y Guo, X Wang… - International …, 2024 - Elsevier
Background Chemotaxis and trafficking of dendritic cells (DCs) induced by cytokine
receptors are crucial steps in rheumatoid arthritis (RA) pathogenesis. C–C chemokine …