Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …

[HTML][HTML] Osteoarthritis year in review 2021: epidemiology & therapy

JG Quicke, PG Conaghan, N Corp, G Peat - Osteoarthritis and cartilage, 2022 - Elsevier
This “Year in review” presents a selection of research themes and individual studies from the
clinical osteoarthritis (OA) field (epidemiology and therapy) and includes noteworthy …

The development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date

WM Oo, C Little, V Duong, DJ Hunter - Drug Design, Development …, 2021 - Taylor & Francis
Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …

Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner

Y Liao, Y Ren, X Luo, AJ Mirando, JT Long… - Science …, 2022 - science.org
Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …

Cartilage calcification in osteoarthritis: mechanisms and clinical relevance

I Bernabei, A So, N Busso, S Nasi - Nature Reviews Rheumatology, 2023 - nature.com
Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …

Repurposed and investigational disease-modifying drugs in osteoarthritis (DMOADs)

WM Oo, DJ Hunter - Therapeutic Advances in …, 2022 - journals.sagepub.com
In spite of a major public health burden with increasing prevalence, current osteoarthritis
(OA) management is largely palliative with an unmet need for effective treatment. Both …

[HTML][HTML] Aging, cell senescence, the pathogenesis and targeted therapies of osteoarthritis

XX Zhang, SH He, X Liang, W Li, TF Li… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a chronic, debilitating joint disease characterized by progressive
destruction of articular cartilage. For a long time, OA has been considered as a degenerative …

[HTML][HTML] Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology

S Grässel, F Zaucke, H Madry - Journal of clinical medicine, 2021 - mdpi.com
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

A systematic literature review informing the consensus statement on efficacy and safety of pharmacological treatment with interleukin-6 pathway inhibition with …

K Kastrati, D Aletaha, GR Burmester, E Chwala… - RMD open, 2022 - rmdopen.bmj.com
Objectives Informing an international task force updating the consensus statement on
efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) …

[HTML][HTML] Overview of first-line and second-line pharmacotherapies for osteoarthritis with special focus on intra-articular treatment

A Nowaczyk, D Szwedowski, I Dallo… - International Journal of …, 2022 - mdpi.com
Osteoarthritis (OA) can be defined as the result of pathological processes of various
etiologies leading to damage to the articular structures. Although the mechanism of …