Synovial inflammation in osteoarthritis progression
E Sanchez-Lopez, R Coras, A Torres… - Nature Reviews …, 2022 - nature.com
Osteoarthritis (OA) is a progressive degenerative disease resulting in joint deterioration.
Synovial inflammation is present in the OA joint and has been associated with radiographic …
Synovial inflammation is present in the OA joint and has been associated with radiographic …
[HTML][HTML] Osteoarthritis year in review 2021: epidemiology & therapy
This “Year in review” presents a selection of research themes and individual studies from the
clinical osteoarthritis (OA) field (epidemiology and therapy) and includes noteworthy …
clinical osteoarthritis (OA) field (epidemiology and therapy) and includes noteworthy …
The development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date
Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …
involvement of varying severity and no regulatory-agency-approved disease-modifying …
Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner
Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …
and anabolic processes in articular cartilage and proinflammatory changes throughout the …
Cartilage calcification in osteoarthritis: mechanisms and clinical relevance
I Bernabei, A So, N Busso, S Nasi - Nature Reviews Rheumatology, 2023 - nature.com
Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be
observed both at the cartilage surface and in its deeper layers. The formation of calcium …
observed both at the cartilage surface and in its deeper layers. The formation of calcium …
Repurposed and investigational disease-modifying drugs in osteoarthritis (DMOADs)
WM Oo, DJ Hunter - Therapeutic Advances in …, 2022 - journals.sagepub.com
In spite of a major public health burden with increasing prevalence, current osteoarthritis
(OA) management is largely palliative with an unmet need for effective treatment. Both …
(OA) management is largely palliative with an unmet need for effective treatment. Both …
[HTML][HTML] Aging, cell senescence, the pathogenesis and targeted therapies of osteoarthritis
XX Zhang, SH He, X Liang, W Li, TF Li… - Frontiers in …, 2021 - frontiersin.org
Osteoarthritis (OA) is a chronic, debilitating joint disease characterized by progressive
destruction of articular cartilage. For a long time, OA has been considered as a degenerative …
destruction of articular cartilage. For a long time, OA has been considered as a degenerative …
[HTML][HTML] Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …
significant health and social problems worldwide, its exact etiology is still unclear. With an …
A systematic literature review informing the consensus statement on efficacy and safety of pharmacological treatment with interleukin-6 pathway inhibition with …
K Kastrati, D Aletaha, GR Burmester, E Chwala… - RMD open, 2022 - rmdopen.bmj.com
Objectives Informing an international task force updating the consensus statement on
efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) …
efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) …
[HTML][HTML] Overview of first-line and second-line pharmacotherapies for osteoarthritis with special focus on intra-articular treatment
Osteoarthritis (OA) can be defined as the result of pathological processes of various
etiologies leading to damage to the articular structures. Although the mechanism of …
etiologies leading to damage to the articular structures. Although the mechanism of …