Opioid use kills tens of thousands of Americans each year, devastates families and entire
communities, and cripples the health care system. Exposure to opioids causes long-term …

Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at
the end of the nineteenth century, its popularity as a recreational drug has ebbed and …

Repeated drug use can change dopamine (DA) function in ways that promote the
development and persistence of addiction, but in what direction? By one view, drug use …

Highlights•Substance use disorders (SUD) involve blunted positive affective and
physiological responses to natural rewards.•Savoring hedonic pleasure from natural …

Background Neuropsychopharmacologic effects of long-term opioid therapy (LTOT) in the
context of chronic pain may result in subjective anhedonia coupled with decreased attention …

Traditional methods for site-specific drug delivery in the brain are slow, invasive, and difficult
to interface with recordings of neural activity. Here, we demonstrate the feasibility and …

Globally, millions of people suffer from various substance use disorders (SUD), including
mono-and polydrug use of opioids and methamphetamine. Brain regions such as the …

Drug-evoked adaptations in the mesolimbic dopamine system are postulated to drive opioid
abuse and addiction. These adaptations vary in magnitude and direction following different …

Clinicians and scientists have begun to recognize that chronic pain and its treatment with
opioid analgesics may occasion hedonic dysregulation—a blunting of physiological and …

Dopamine (DA) neurotransmission is critical in the neurobiology of reward and aversion, but
its contribution to the aversive state of opioid withdrawal remains unknown in humans. To …