Botulinum Toxin Intervention in Cerebral Palsy-Induced Spasticity Management: Projected and Contradictory Effects on Skeletal Muscles

CS Kaya Keles, F Ates - Toxins, 2022 - mdpi.com
Spasticity, following the neurological disorder of cerebral palsy (CP), describes a
pathological condition, the central feature of which is involuntary and prolonged muscle …

Botulinum toxin: from poison to possible treatment for spasticity in spinal cord injury

R Palazón-García… - International Journal of …, 2021 - mdpi.com
Botulism has been known for about three centuries, and since its discovery, botulinum toxin
has been considered one of the most powerful toxins. However, throughout the 20th century …

[HTML][HTML] Measuring effects on pain and quality of life after abobotulinum toxin A injections in children with cerebral palsy

C Wong, I Westphall, JS Michelsen - Toxins, 2022 - mdpi.com
Sixty-seven percent of children with cerebral palsy (CCP) experience pain. Pain is closely
interrelated to diminished quality of life. Despite this, pain is an overlooked and undertreated …

Safety profile and lack of immunogenicity of incobotulinumtoxinA in pediatric spasticity and sialorrhea: A pooled analysis

S Berweck, M Banach, D Gaebler-Spira, HG Chambers… - Toxins, 2022 - mdpi.com
IncobotulinumtoxinA, a pure botulinumtoxinA formulation, is free of accessory proteins. This
analysis provides pooled safety data from phase 3 trials of children/adolescents (2–17 …

[HTML][HTML] IncobotulinumtoxinA for the treatment of lower-limb spasticity in children and adolescents with cerebral palsy: A phase 3 study

F Heinen, P Kanovský, AS Schroeder… - Journal of pediatric …, 2021 - content.iospress.com
PURPOSE: Investigate the efficacy and safety of multipattern incobotulinumtoxinA injections
in children/adolescents with lower-limb cerebral palsy (CP)-related spasticity. METHODS …

[HTML][HTML] Ex vivo adult stem cell characterization from multiple muscles in ambulatory children with cerebral palsy during early development of contractures

M Corvelyn, J Meirlevede, J Deschrevel, E Huyghe… - Differentiation, 2023 - Elsevier
Cerebral palsy (CP) is one of the most common conditions leading to lifelong childhood
physical disability. Literature reported previously altered muscle properties such as lower …

[HTML][HTML] Botulinum Toxin Intervention in Cerebral Palsy-Induced Spasticity Management: Projected and Contradictory Effects on Skeletal Muscles

CSK Keles, F Ates - Toxins, 2022 - ncbi.nlm.nih.gov
Spasticity, following the neurological disorder of cerebral palsy (CP), describes a
pathological condition, the central feature of which is involuntary and prolonged muscle …

[HTML][HTML] Quantification and Monitoring of the Effect of Botulinum Toxin A on Paretic Calf Muscles of Children With Cerebral Palsy With MRI: A Preliminary Study

C Weidensteiner, P Madoerin, X Deligianni… - Frontiers in …, 2021 - frontiersin.org
Background: Muscles from patients with cerebral palsy (CP) are often spastic and form
contractures that limit the range of motion. Injections of botulinum toxin A (BTX) into the calf …

[HTML][HTML] Approach to the treatment of pediatric dystonia

C Gorodetsky, A Fasano - Dystonia, 2022 - frontierspartnerships.org
Dystonia is the most common movement disorder in the pediatric population. It can affect
normal motor development and cause significant motor disability. The treatment of pediatric …

[HTML][HTML] The Relationship between Pain and Spasticity and Tell-Tale Signs of Pain in Children with Cerebral Palsy

C Wong - Toxins, 2023 - mdpi.com
Pain and quality of life are closely interrelated in children with cerebral palsy (CCP). Even
though 67% of CCP experience pain, it is overlooked and untreated. In this study, our …