Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people …

The ability to reprogram adult somatic cells back to pluripotency presents a powerful tool for
studying cell-fate identity and modeling human disease. However, the reversal of cellular …

Modeling late-onset disorders such as Parkinson's disease (PD) using iPSC technology
remains a challenge, as current differentiation protocols yield cells with the properties of fetal …

Human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) are
considered as a promising cell source for transplantation and have been used for organoid …

Several protocols have been developed for human induced pluripotent stem cell neuronal
differentiation. We compare several methods for forebrain cortical neuronal differentiation by …

Several shortcomings of current Parkinson's disease (PD) models limit progress in
identification of environmental contributions to disease pathogenesis. The conditionally …

Background Studying human ageing is of increasing importance due to the worldwide
ageing population. However, it faces the challenge of lengthy experiments to produce an …

In vitro manipulation of human stem cells is a critical process in regenerative medicine and
cellular therapies. Strategies and methods to maintain stem cells and direct them into …

The development of three-dimensional culture methods has allowed for the study of
developing cortical morphology in human cells. This provides a new tool to study the …

Epilepsy is a chronic brain disease and, considering the amount of people affected of all
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …