Polymeric nanoparticles for drug delivery in glioblastoma: State of the art and future perspectives

F Madani, SS Esnaashari, TJ Webster… - Journal of Controlled …, 2022 - Elsevier
Glioblastoma (GBM) is an aggressive, fatal and malignant primary brain tumor. Despite the
current standard treatment for glioblastoma patients including neurosurgical resection …

Cryo-shocked cancer cells as an oncolytic adenovirus reservoir for glioblastoma immunotherapy

X Liu, J Xu, T Yao, J Ding, S Li, R Su… - … Applied Materials & …, 2022 - ACS Publications
Glioblastoma is the most common type of primary brain tumor, which has a high recurrence
rate and a high mortality rate. Immunotherapy shows promise in cancer therapy due to its …

ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem …

Z Gao, J Xu, Y Fan, Z Zhang, H Wang, M Qian… - Journal of Experimental …, 2022 - Springer
Background Intratumoral heterogeneity is the primary challenge in the treatment of
glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion …

A novel protein encoded by ZCRB1-induced circHEATR5B suppresses aerobic glycolysis of GBM through phosphorylation of JMJD5

J Song, J Zheng, X Liu, W Dong, C Yang… - Journal of Experimental …, 2022 - Springer
Background RNA-binding proteins (RBPs) and circular RNAs (circRNAs) play important
roles in glioblastoma multiforme (GBM). Aerobic glycolysis is a metabolic characteristic of …

RNA regulation of inflammatory responses in glia and its potential as a therapeutic target in central nervous system disorders

A Guha, MA Husain, Y Si, LB Nabors, N Filippova… - Glia, 2023 - Wiley Online Library
A major hallmark of neuroinflammation is the activation of microglia and astrocytes with the
induction of inflammatory mediators such as IL‐1β, TNF‐α, iNOS, and IL‐6 …

[HTML][HTML] Inhibition of the RNA regulator HuR by SRI-42127 attenuates neuropathic pain after nerve injury through suppression of neuroinflammatory responses

RE Sorge, Y Si, LA Norian, A Guha, GE Moore… - …, 2022 - Elsevier
Microglial activation with the production of pro-inflammatory mediators such as IL-6, TNF-α,
and IL-1β, is a major driver of neuropathic pain (NP) following peripheral nerve injury. We …

Post-transcriptional modifications of RNA as regulators of apoptosis in glioblastoma

A Dome, M Dymova, V Richter, G Stepanov - International Journal of …, 2022 - mdpi.com
This review is devoted to changes in the post-transcriptional maturation of RNA in human
glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The …

The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes

RAS Barreiro, GDA Guardia, FM Meliso, X Lei, WQ Li… - RNA biology, 2023 - Taylor & Francis
The exon junction complex (EJC) plays key roles throughout the lifespan of RNA and is
particularly relevant in the nervous system. We investigated the roles of two EJC members …

ELAVL2 loss promotes aggressive mesenchymal transition in glioblastoma

Y Kim, JH You, Y Ryu, G Park, U Lee, HE Moon… - NPJ Precision …, 2024 - nature.com
Glioblastoma (GBM), the most lethal primary brain cancer, exhibits intratumoral
heterogeneity and molecular plasticity, posing challenges for effective treatment. Despite …

HuR‐positive stress granules: Potential targets for age‐related osteoporosis

Y Huai, X Wang, W Mao, X Wang, Y Zhao, X Chu… - Aging …, 2024 - Wiley Online Library
Aging impairs osteoblast function and bone turnover, resulting in age‐related bone
degeneration. Stress granules (SGs) are membrane‐less organelles that assemble in …